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Product Details
MUB1806P
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
F5S F6.2
Immunogen
TIAM
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A/G
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
F5S F6.2 is a Mouse monoclonal directed anti the N-terminal region of Tiam1.
The antibody may be stored at 4°C. For prolonged storage prepare appropriate aliquots and store at or below -20°C. Prior to use, an aliquot is thawed slowly in the dark at ambient temperature, spun down again and used to prepare working dilutions by adding sterile phosphate buffered saline (PBS, pH 7.2). Repeated thawing and freezing should be avoided. Working dilutions should be stored at 4°C, not refrozen, and preferably used the same day. If a slight precipitation occurs upon storage, this should be removed by centrifugation. It will not affect the performance or the concentration of the product.
Target Information
Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Required for normal cell adhesion and cell migration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: human T-lymphoma invasion and metastasis inducing TIAM1 protein; Rho guanine nucleotide exchange factor TIAM1; T-lymphoma invasion and metastasis-inducing protein 1; TIAM-1
Gene Aliases: TIAM1
UniProt ID: (Human) Q13009
Entrez Gene ID: (Human) 7074
cardiac muscle hypertrophy
apoptotic process
cell-matrix adhesion
cell migration
Rac protein signal transduction
positive regulation of protein binding
regulation of Rho protein signal transduction
response to cocaine
positive regulation of apoptotic process
positive regulation of JUN kinase activity
ephrin receptor signaling pathway
positive regulation of axonogenesis
regulation of small GTPase mediated signal transduction
Wnt signaling pathway, planar cell polarity pathway
positive regulation of dendritic spine morphogenesis
regulation of insulin secretion involved in cellular response to glucose stimulus
regulation of ERK1 and ERK2 cascade
protein localization to membrane
activation of GTPase activity
positive regulation of Schwann cell chemotaxis
regulation of dopaminergic neuron differentiation
neuron projection extension
regulation of non-canonical Wnt signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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