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Invitrogen
TIAM1 Polyclonal Antibody
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FIGURE: 1 / 2
TIAM1 Antibody (PA5-142082) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of TIAM1 in U2OS cells using TIAM1 Polyclonal Antibody (Product # PA5-142082). Cells were fixed with paraformaldehyde, permeabilized with 0.15% Triton, and incubated with the primary antibody for 1hr (10 µg/mL) followed by Alexa Fluor 488 secondary antibody (4 µg/mL), showing nuclear and cytoplasmic staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10 µg/mL) followed by Alexa Fluor 488 secondary antibody (4 µg/mL).
Product Details
PA5-142082
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide with sequence C-EDFAPSRKLNTEI.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2932743
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
Target Information
Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Required for normal cell adhesion and cell migration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: human T-lymphoma invasion and metastasis inducing TIAM1 protein; Rho guanine nucleotide exchange factor TIAM1; T-lymphoma invasion and metastasis-inducing protein 1; TIAM-1
Gene Aliases: TIAM1
UniProt ID: (Human) Q13009
Entrez Gene ID: (Human) 7074
cardiac muscle hypertrophy
apoptotic process
cell-matrix adhesion
cell migration
Rac protein signal transduction
positive regulation of protein binding
regulation of Rho protein signal transduction
response to cocaine
positive regulation of apoptotic process
positive regulation of JUN kinase activity
ephrin receptor signaling pathway
positive regulation of axonogenesis
regulation of small GTPase mediated signal transduction
Wnt signaling pathway, planar cell polarity pathway
positive regulation of dendritic spine morphogenesis
regulation of insulin secretion involved in cellular response to glucose stimulus
regulation of ERK1 and ERK2 cascade
protein localization to membrane
activation of GTPase activity
positive regulation of Schwann cell chemotaxis
regulation of dopaminergic neuron differentiation
neuron projection extension
regulation of non-canonical Wnt signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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