Proteintech

TICAM1 Polyclonal Antibody

TICAM1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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TICAM1 Antibody (23288-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human testis tissue slide using 23288-1-AP (TRIF/TICAM1 antibody) at dilution of 1:200 (under 40x lens).

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Product Details

23288-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 15 publications 15 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TRIF/TICAM1 Fusion Protein Ag19779 (513-712 aa encoded by BC035331)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: LDEHSQIFA RKVANTFKPH RLQARKAMWR KEQDTRALRE QSQHLDGERM QAAALNAAYS AYLQSYLSYQ AQMEQLQVAF GSHMSFGTGA PYGARMPFGG QVPLGAPPPF PTWPGCPQPP PLHAWQAGTP PPPSPQPAAF PQSLPFPQSP AFPTASPAPP QSPGLQPLII HHAQMVQLGL NNHMWNQRGS QAPEDKTQEA E (513-712 aa encoded by BC035331)

Target Information

Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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SARS-CoV-2 NSP8 suppresses type I and III IFN responses by modulating the RIG-I/MDA5, TRIF, and STING signaling pathways.

Journal of medical virology

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Sat Apr 01 00:00:00 UTC 2023

The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis.

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Developmental exposure to chlorpyrifos causes neuroinflammation via necroptosis in mouse hippocampus and human microglial cell line.

Environmental pollution (Barking, Essex : 1987)

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Palmitic Acid Promotes Lung Metastasis of Melanomas via the TLR4/TRIF-Peli1-pNF-κB Pathway.

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Thu Nov 17 00:00:00 UTC 2022

Palmitic Acid Promotes Lung Metastasis of Melanomas via the TLR4/TRIF-Peli1-pNF-κB Pathway.

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Zhang X,Li X,Xiong G,Yun F,Feng Y,Ni Q,Wu N,Yang L,Yi Z,Zhang Q,Yang Z,Kuang Y,Sai B,Zhu Y

Thu Nov 17 00:00:00 UTC 2022

Palmitic Acid Promotes Lung Metastasis of Melanomas via the TLR4/TRIF-Peli1-pNF-κB Pathway.

Metabolites

Zhang X,Li X,Xiong G,Yun F,Feng Y,Ni Q,Wu N,Yang L,Yi Z,Zhang Q,Yang Z,Kuang Y,Sai B,Zhu Y

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Lycopene-Loaded Bilosomes Ameliorate High-Fat Diet-Induced Chronic Nephritis in Mice through the TLR4/MyD88 Inflammatory Pathway.

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Metallothionein 3-Zinc Axis Suppresses Caspase-11 Inflammasome Activation and Impairs Antibacterial Immunity.

Frontiers in immunology

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TLR4-NLRP3-GSDMD-Mediated Pyroptosis Plays an Important Role in Aggravated Liver Injury of CD38^-/- Sepsis Mice.

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The N6-methyladenosine RNA-binding protein YTHDF1 modulates the translation of TRAF6 to mediate the intestinal immune response.

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Monophosphoryl lipid a attenuates radiation injury through TLR4 activation.

Oncotarget

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Monophosphoryl lipid a attenuates radiation injury through TLR4 activation.

Oncotarget

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Oncotarget

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Bioinformatics

Protein Aliases: hCG_39321; HSD34; MyD88-3; Proline-rich, vinculin and TIR domain-containing protein B; Putative NF-kappa-B-activating protein 502H; RNF36; TI; TICAM-1; TIR domain containing adaptor inducing interferon-beta; TIR domain-containing adapter molecule 1; TIR domain-containing adapter protein inducing IFN-beta; Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta; toll-like receptor adaptor molecule 1

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Gene Aliases: IIAE6; MyD88-3; PRVTIRB; TICAM-1; TICAM1; TRIF

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UniProt ID: (Human) Q8IUC6

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Entrez Gene ID: (Human) 148022

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Function(s)

signal transducer activity protein binding protein kinase binding

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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TICAM1 Polyclonal Antibody

TICAM1 Antibody (23288-1-AP) in IHC (P)

Product Details

23288-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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