Fabgennix

TIE2 Polyclonal Antibody, Biotin

View all (53) TIE2 (TEK) antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

TIE2-BIOTIN

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (IHC)

1:50-1:250
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-

Dot blot (DB)

1:10,000
-
Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide taken within amino acid region 540-590 on human Tyrosine-protein kinase receptor Tie-1 isoform 2 protein.
View immunogen

Conjugate

Biotin Biotin Biotin

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells. TEK signaling appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis, and defects in TEK are associated with inherited venous malformations. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Immunoblotting showed that TIE2 expression was increased by thyroid-stimulating hormone and agents that increased intracellular cAMP. HSCs expressing the receptor tyrosine kinase TIE2 are quiescent and antiapoptotic and comprise a side population of HSCs that adhere to osteoblasts in the bone marrow niche.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Angiopoietin-1 receptor; CD202b; CD202b antigen; EC 2.7.10; EC 2.7.10.1; Endothelial tyrosine kinase; endothelial-specific receptor tyrosine kinase; HYK; mTIE2; p140 TEK; STK1; TEKT1; Tektin-1; Tunica interna endothelial cell kinase; Tyrosine kinase with Ig and EGF homology domains-2; tyrosine kinases that contain immunoglobulin-like loops and epidermal growth factor-similar domains 2; Tyrosine-protein kinase receptor TEK; Tyrosine-protein kinase receptor TIE-2

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Gene Aliases: AA517024; Cd202b; Hyk; STK1; Tek; Tie-2; Tie2

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UniProt ID: (Mouse) Q02858

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Entrez Gene ID: (Mouse) 21687, (Rat) 89804

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Function(s)
nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity receptor activity protein binding ATP binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups growth factor binding receptor signaling protein tyrosine kinase activity
Process(es)
angiogenesis patterning of blood vessels vasculogenesis positive regulation of protein phosphorylation endothelial cell proliferation regulation of endothelial cell proliferation sprouting angiogenesis positive regulation of cytokine secretion involved in immune response protein phosphorylation cell-matrix adhesion transmembrane receptor protein tyrosine kinase signaling pathway heart development positive regulation of endothelial cell migration positive regulation of phosphatidylinositol 3-kinase signaling phosphorylation single organismal cell-cell adhesion negative regulation of angiogenesis peptidyl-tyrosine phosphorylation hemopoiesis regulation of cell migration positive regulation of vascular endothelial growth factor receptor signaling pathway response to retinoic acid regulation of establishment or maintenance of cell polarity positive regulation of peptidyl-serine phosphorylation substrate adhesion-dependent cell spreading intracellular signal transduction positive regulation of protein import into nucleus negative regulation of apoptotic process positive regulation of phosphatidylinositol 3-kinase activity response to estrogen regulation of angiogenesis positive regulation of angiogenesis positive regulation of cell adhesion protein autophosphorylation Tie signaling pathway protein oligomerization positive regulation of focal adhesion assembly positive regulation of protein kinase B signaling heart trabecula formation positive regulation of ERK1 and ERK2 cascade regulation of NIK/NF-kappaB signaling positive regulation of intracellular signal transduction positive regulation of actin cytoskeleton reorganization negative regulation of endothelial cell apoptotic process response to hypoxia endochondral ossification response to organic substance signal transduction by protein phosphorylation organ regeneration response to peptide hormone response to cAMP
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