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Invitrogen
TIMD2 Polyclonal Antibody
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FIGURE: 1 / 1
TIMD2 Antibody (PA5-47995) in IHC (F)
Immunohistochemical analysis of TIMD2 in perfusion fixed frozen sections of mouse liver. Samples were incubated with TIMD2 polyclonal antibody (Product # PA5-47995) using a dilution of 1.7 µg/mL for 1 hour at room temperature followed by Anti-Goat IgG VisUCyte™ HRP Polymer Antibody. Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to sinusoids.
Product Details
PA5-47995
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse TIM-2 Met1-Asn229
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2606503
Product Specific Information
In direct ELISAs and Western blots, less than 2% cross-reactivity with recombinant human TIM-1 and recombinant mouse TIM-3 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
TIM-2 recognizes T-cell immunoglobulin mucin 2, a transmembrane glycoprotein and member of the immunoglobulin superfamily, expressed by activated lymphocytes, developmentally in the 8-cell embryo and blastocyst, and preferentially up-regulated in Th2 cells and down-regulated in Th1 cells. Tim-2 acts as a negative regulator of Th2 cells, and is implicated to play a critical role in the development of atopic disease and other Th2-biased immune responses. Tim-2 also acts as a receptor for Semaphorin 4A, a transmembrane protein expressed on dendritic cells and B cells, which plays a role in the guidance of axonal migration during neuronal development, and has been shown to enhance T cell activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: T-cell immunoglobulin and mucin domain containing 2; T-cell immunoglobulin and mucin domain-containing protein 2; T-cell immunoglobulin mucin receptor 2; T-cell membrane protein 2; TIM-2; TIMD-2
Gene Aliases: AA816106; AU019358; AU019662; C78111; G9D3; TIM-2; Tim2; Timd2
UniProt ID: (Mouse) Q8R183
Entrez Gene ID: (Mouse) 171284
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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