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Product Details
11179-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TIMM8A Fusion Protein Ag1661 (1-97 aa encoded by BC015093)
Conjugate
Form
Liquid
Concentration
0.6 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MDSSSSSSA AGLGAVDPQL QHFIEVETQK QRFQQLVHQM TELCWEKCMD KPGPKLDSRA EACFVNCVER FIDTSQFILN RLEQTQKSKP VFSESLSD (1-97 aa encoded by BC015093)
Target Information
Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins. Probably necessary for normal neurologic development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Deafness dystonia protein 1; Deafness dystonia protein 1 homolog; deafness/dystonia peptide; Mitochondrial import inner membrane translocase subunit Tim8 A; translocase of inner mitochondrial membrane 8 homolog a; translocase of inner mitochondrial membrane 8 homolog a1; X-linked deafness dystonia protein
Gene Aliases: DDP; DDP1; DFN1; DXHXS1274E; Fci-12; MTS; TIM8; TIM8A; TIMM8A; Timm8a1
UniProt ID: (Human) O60220, (Mouse) Q9WVA2, (Rat) Q9WVA1
Entrez Gene ID: (Human) 1678, (Mouse) 30058, (Rat) 84383
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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