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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • TIMP2 Antibodies

          Proteintech

          TIMP-2 Polyclonal Antibody

          36 References
          View all (68) TIMP2 antibodies

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          Datasheet
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          Cite TIMP-2 Polyclonal Antibody

          • Antibody Testing Data (2)
          TIMP-2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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          TIMP-2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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          FIGURE: 1 / 2

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          TIMP-2 Antibody (17353-1-AP) in IHC (P)

          Immunohistochemistry of paraffin-embedded human kidney tissue slide using 17353-1-AP ( TIMP-2 antibody at dilution of 1:200 (under 40x lens). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          TIMP-2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          TIMP-2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

          Product Details

          17353-1-AP

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:2,000
          View 28 publications 28 publications

          Immunohistochemistry (IHC)

          -
          View 7 publications 7 publications

          Immunohistochemistry (Paraffin) (IHC (P))

          1:50-1:500
          -

          Immunocytochemistry (ICC/IF)

          -
          View 1 publication 1 publication
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Published species

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          TIMP-2 Fusion Protein Ag10051 (6-220 aa encoded by BC052605)
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          0.18 mg/mL

          Purification

          Antigen affinity chromatography

          Storage buffer

          PBS, pH 7.3, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Wet ice (domestic); Dry ice (international)

          Product Specific Information

          Immunogen sequence: RTLRLALGL LLLATLLRPA DACSCSPVHP QQAFCNADVV IRAKAVSEKE VDSGNDIYGN PIKRIQYEIK QIKMFKGPEK DIEFIYTAPS SAVCGVSLDV GGKKEYLIAG KAEGDGKMHI TLCDFIVPWD TLSTTQKKSL NHRYQMGCEC KITRCPMIPC YISSPDECLW MDWVTEKNIN GHQAKFFACI KRSDGSCAWY RGAAPPKQEF LDIEDP (6-220 aa encoded by B C052605)

          Target Information

          TIMP-1 and TIMP-2 are inhibitory enzymes of matrix metalloproteinase family, and are thought to be of great importance in the maintenance of connective tissue integrity. TIMP-2 shows the highest binding affinity to both the latent (pro) and active forms of 72 kDa Type IV collagenase (also known as MMP-2 or gelatinase A). It also has affinity for the active form of 92 kDa Type IV collagenase (also known as MMP-9 or gelatinase B). TIMP-2 inhibits the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: CSC-21K; Metalloproteinase inhibitor 2; testicular secretory protein Li 57; TIMP 2; TIMP-2; tissue inhibitor of metalloproteinase 2; Tissue inhibitor of metalloproteinases 2

          View more View less

          Gene Aliases: CSC-21K; D11Bwg1104e; DDC8; Timp-2; TIMP2

          View more View less

          UniProt ID: (Human) P16035, (Rat) P30121

          View more View less

          Entrez Gene ID: (Human) 7077, (Rat) 29543, (Mouse) 21858

          View more View less

          Function(s)
          protease binding integrin binding protein binding metalloendopeptidase inhibitor activity metal ion binding enzyme activator activity enzyme inhibitor activity peptidase inhibitor activity
          Process(es)
          spermatogenesis central nervous system development aging negative regulation of cell proliferation response to hormone negative regulation of endopeptidase activity regulation of cAMP metabolic process regulation of Rap protein signal transduction response to cytokine response to drug positive regulation of catalytic activity negative regulation of catalytic activity regulation of MAPK cascade positive regulation of MAPK cascade regulation of neuron differentiation positive regulation of neuron differentiation positive regulation of adenylate cyclase activity negative regulation of proteolysis negative regulation of mitotic cell cycle negative regulation of Ras protein signal transduction negative regulation of membrane protein ectodomain proteolysis cellular response to organic substance extracellular matrix disassembly negative regulation of peptidase activity
          It has to be done as per old AB suggested Products section.
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