Proteintech

TIMP-4 Polyclonal Antibody

TIMP-4 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 9

TIMP-4 Antibody (12326-1-AP) in ICC/IF

Immunofluorescent analysis of MCF-7 cells using 12326-1-AP (TIMP-4 antibody) at dilution of 1:25 and Rhodamine-Goat anti-Rabbit IGG.

TIMP-4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

12326-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TIMP-4 Fusion Protein Ag2927 (1-224 aa encoded by BC010553)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MPGSPRPAP SWVLLLRLLA LLRPPGLGEA CSCAPAHPQQ HICHSALVIR AKISSEKVVP ASADPADTEK MLRYEIKQIK MFKGFEKVKD VQYIYTPFDS SLCGVKLEAN SQKQYLLTGQ VLSDGKVFIH LCNYIEPWED LSLVQRESLN HHYHLNCGCQ ITTCYTVPCT ISAPNECLWT DWLLERKLYG YQAQHYVCMK HVDGTCSWYR GHLPLRKEFV DIVQP (1-224 aa encoded by BC010553)

Target Information

Tissue inhibitor of metalloproteinase 4 (TIMP4) is encoded by the gene TIMP4 located on chromosome 3. It belongs to the family of TIMP genes and is known to inhibit the activity of matrix metalloproteinases. Matrix metalloproteinases (MMP) are a group of proteinases that degrade the components of extracellular matrix. TIMP4 irreversibly binds to MMPs and inactivates them with the help of zinc as a cofactor. The netrin domain of TIMP4 is involved in platelet recruitment and aggregation. Other biological functions include response to cytokine and peptide hormone stimuli and involvement with the ovulation cycle and CNS development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Discovery of a Novel Small-Molecule Inhibitor Disrupting TRBP-Dicer Interaction against Hepatocellular Carcinoma via the Modulation of microRNA Biogenesis.

Journal of medicinal chemistry

Peng T,He Y,Wang T,Yu J,Ma X,Zhou Z,Sheng Y,Li L,Peng H,Li S,Zou J,Yuan Y,Zhao Y,Shi H,Li F,Liu W,Hu K,Lu X,Zhang G,Wang F

Thu Aug 25 00:00:00 UTC 2022

Coxsackievirus A2 Leads to Heart Injury in a Neonatal Mouse Model.

Viruses

Ji W,Zhu P,Liang R,Zhang L,Zhang Y,Wang Y,Zhang W,Tao L,Chen S,Yang H,Jin Y,Duan G

Wed Aug 11 00:00:00 UTC 2021

Coxsackievirus A2 Leads to Heart Injury in a Neonatal Mouse Model.

Viruses

Ji W,Zhu P,Liang R,Zhang L,Zhang Y,Wang Y,Zhang W,Tao L,Chen S,Yang H,Jin Y,Duan G

Wed Aug 11 00:00:00 UTC 2021

Apatinib Inhibits the Invasion and Metastasis of Liver Cancer Cells by Downregulating MMP-Related Proteins via Regulation of the NF-κB Signaling Pathway.

BioMed research international

He X,Huang Z,Liu P,Li Q,Wang M,Qiu M,Xiong Z,Yang S

Wed Apr 28 00:00:00 UTC 2021

Fructose-1,6-bisphosphate prevents pulmonary fibrosis by regulating extracellular matrix deposition and inducing phenotype reversal of lung myofibroblasts.

PloS one

Dias HB,de Oliveira JR,Donadio MVF,Kimura S

Thu Apr 02 00:00:00 UTC 2020

Molecularly targeted anti-cancer drugs inhibit the invasion and metastasis of hepatocellular carcinoma by regulating the expression of MMP and TIMP gene families.

Biochemical and biophysical research communications

He XX,Shi LL,Qiu MJ,Li QT,Wang MM,Xiong ZF,Yang SL

Fri Oct 12 00:00:00 UTC 2018

Molecularly targeted anti-cancer drugs inhibit the invasion and metastasis of hepatocellular carcinoma by regulating the expression of MMP and TIMP gene families.

Biochemical and biophysical research communications

He XX,Shi LL,Qiu MJ,Li QT,Wang MM,Xiong ZF,Yang SL

Fri Oct 12 00:00:00 UTC 2018

Bioinformatics

Protein Aliases: Metalloproteinase inhibitor 4; TIMP 4; TIMP-4; tissue inhibitor of metalloproteinase 4; Tissue inhibitor of metalloproteinases 4

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Gene Aliases: TIMP4

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UniProt ID: (Human) Q99727

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Entrez Gene ID: (Human) 7079

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Function(s)

protease binding metalloendopeptidase inhibitor activity metal ion binding

Process(es)

Notch signaling pathway central nervous system development biological_process response to organic substance negative regulation of endopeptidase activity response to lipopolysaccharide response to cytokine response to drug ovulation cycle negative regulation of catalytic activity response to peptide hormone negative regulation of membrane protein ectodomain proteolysis

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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TIMP-4 Polyclonal Antibody

TIMP-4 Antibody (12326-1-AP) in ICC/IF

Product Details

12326-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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