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NeoBiotechnologies
TIMP2 (Tissue Inhibitor of Metalloproteinase 2) Monoclonal Antibody (SPM356)
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Product Details
7077-MSM1X-P0
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Guinea pig,
Human,
Mouse,
Rabbit,
Rat,
Zebrafish
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
SPM356
Immunogen
A synthetic peptide from the N-terminus of human TIMP2 protein (aa56-66) (DSGNDIYGNPI)
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C, do not freeze
Shipping conditions
Wet ice
Target Information
TIMP-1 and TIMP-2 are inhibitory enzymes of matrix metalloproteinase family, and are thought to be of great importance in the maintenance of connective tissue integrity. TIMP-2 shows the highest binding affinity to both the latent (pro) and active forms of 72 kDa Type IV collagenase (also known as MMP-2 or gelatinase A). It also has affinity for the active form of 92 kDa Type IV collagenase (also known as MMP-9 or gelatinase B). TIMP-2 inhibits the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Collagenase inhibitor; CSC-21K; Metalloproteinase inhibitor 2; metalloproteinase inhibitor TIMP-2; testicular secretory protein Li 57; TIMP 2; TIMP metallopeptidase inhibitor 2; TIMP-2; tissue inhibitor of metalloproteinase 2; tissue inhibitor of metalloproteinase 2a; tissue inhibitor of metalloproteinase-2; Tissue inhibitor of metalloproteinases 2; tissue inhibitor of mettaloproteinase 2
Gene Aliases: BOS_19535; CSC-21K; D11Bwg1104e; DDC8; etID32613.12; fa96h09; Timp-2; TIMP2; wu:fa96h09; zgc:136726
UniProt ID: (Bovine) P16368, (Human) P16035, (Rat) P30121, (Guinea pig) Q9WUC6
Entrez Gene ID: (Rabbit) 100008689, (Bovine) 282093, (Human) 7077, (Rat) 29543, (Guinea pig) 100135629, (Mouse) 21858, (Zebrafish) 359835
spermatogenesis
central nervous system development
aging
negative regulation of cell proliferation
response to hormone
negative regulation of endopeptidase activity
regulation of cAMP metabolic process
regulation of Rap protein signal transduction
response to cytokine
response to drug
positive regulation of catalytic activity
negative regulation of catalytic activity
regulation of MAPK cascade
positive regulation of MAPK cascade
regulation of neuron differentiation
positive regulation of neuron differentiation
positive regulation of adenylate cyclase activity
negative regulation of proteolysis
negative regulation of mitotic cell cycle
negative regulation of Ras protein signal transduction
negative regulation of membrane protein ectodomain proteolysis
cellular response to organic substance
extracellular matrix disassembly
response to organic substance
negative regulation of peptidase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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