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Immunogen sequence: MPQNEYIEL HRKRYGYRLD YHEKKRKKES REAHERSKKA KKMIGLKAKL YHKQRHAEKI QMKKTIKMHE KRNTKQKNDE KTPQGAVPAY LLDREGQSRA KVLSNMIKQK RKEKAGKWEV PLPKVRAQGE TEVLKVIRTG KRKKKAWKRM VTKVCFVGDG FTRKPPKYER FIRPMGLRFK KAHVTHPELK ATFCLPILGV KKNPSSPLYT TLGVITKGTV IEVNVSELGL VTQGGKVIWG KYAQVTNNPE NDGCINAVLL V (1-260 aa encoded by BC005288)
This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: FLJ94393; Hairy cell leukemia protein 1; NSA2 ribosome biogenesis homolog; Ribosome biogenesis protein NSA2 homolog; TGF beta-inducible nuclear protein 1; TGF-beta inducible nuclear protein; TGF-beta-inducible nuclear protein 1; YR-29
Gene Aliases: CDK105; HCL-G1; HCLG1; HUSSY-29; HUSSY29; NSA2; TINP1
UniProt ID: (Human) O95478
Entrez Gene ID: (Human) 10412
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