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Proteintech
TIP47 Monoclonal Antibody (4C11B1), CoraLite® 555
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Product Details
CL555-66523
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
4C11B1
Immunogen
Recombinant protein
Conjugate
Excitation/Emission Max
555/570 nm
Form
Liquid
Purification
Protein G
Storage buffer
PBS with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: EMVSSAKDTV ATQLSEAVDA TRGAVQSGVD KTKSVVTGGV QSVMGSRLGQ MVLSGVDTVL GKSEEWADNH LPLTDAELAR IATSLDGFDV ASVQQQRQEQ SYFVRLGSLS ERLRQHAYEH SLGKLRATKQ RAQEALLQLS QALSLMETVK QGVDQKLVEG QEKLHQMWLS WNQKQLQGPE KEPPKPEQVE SRALTMFRDI AQQLQATCTS LGSSIQGLPT NVKDQVQQAR RQVEDLQATF SSIHSFQDLS SSILAQSRER VASAREALDH MVEYVAQNTP VTWLVGPFAP GITEKAPEEK K
Target Information
TIP47 has been described as cargo protein involved in the trafficking of the mannose-6-phosphate receptor between endosomes and the Golgi complex. Mannose 6-phophate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs and is required for endosome to Golgi transport. This protein also binds directly to the GTPase RAB9, a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo. TIP47 has been localized in milk fat globule membranes of human and bovine origin. It has been described as a placental protein, as well. Increased amounts of TIP47 are secreted into circulation of cervix carcinoma patients. Therefore, this protein is probably significant as an oncodevelopmental marker.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 47 kDa mannose 6-phosphate receptor-binding protein; 47 kDa MPR-binding protein; Cargo selection protein TIP47; Mannose-6-phosphate receptor-binding protein 1; MGC11117; MGC2012; Perilipin-3; Placental protein 17; PP17; tail-interacting protein, 47 kD; testicular tissue protein Li 114
Gene Aliases: M6PRBP1; PLIN3; PP17; TIP47
UniProt ID: (Human) O60664
Entrez Gene ID: (Human) 10226
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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