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Invitrogen
TIPIN Polyclonal Antibody
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TIPIN Antibody (PA5-87828) in WB
Western blot analysis of TIPIN in extracts of various cell lines. Samples were incubated with TIPIN Polyclonal antibody (Product # PA5-87828) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
Product Details
PA5-87828
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-301 of human TIPIN (NP_0603282)
Conjugate
Form
Liquid
Concentration
1.23 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2804436
Product Specific Information
Immunogen sequence: MLEPQENGVI DLPDYEHVED ETFPPFPPPA SPERQDGEGT EPDEESGNGA PVPVPPKRTV KRNIPKLDAQ RLISERGLPA LRHVFDKAKF KGKGHEAEDL KMLIRHMEHW AHRLFPKLQF EDFIDRVEYL GSKKEVQTCL KRIRLDLPIL HEDFVSNNDE VAENNEHDVT STELDPFLTN LSESEMFASE LSRSLTEEQQ QRIERNKQLA LERRQAKLLS NSQTLGNDML MNTPRAHTVE EVNTDEDQKE ESNGLNEDIL DNPCNDAIAN TLNEEETLLD QSFKNVQQQL DATSRNITEA R; Positive Samples: 293T, HeLa, MCF-7; Cellular Location: Cytoplasm, Nucleus
Target Information
Required for normal progression of S-phase. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CSM3 homolog; FLJ20516; TIMELESS-interacting protein
Gene Aliases: 1110005A05Rik; 1110018P21Rik; TIPIN
UniProt ID: (Human) Q9BVW5, (Mouse) Q91WA1
Entrez Gene ID: (Human) 54962, (Mouse) 66131
DNA replication checkpoint
DNA damage checkpoint
cellular response to DNA damage stimulus
cell cycle
mitotic nuclear division
positive regulation of cell proliferation
response to UV
intra-S DNA damage checkpoint
cell cycle phase transition
replication fork protection
cell division
DNA replication
regulation of nuclear cell cycle DNA replication
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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