Invitrogen

TIRAP Polyclonal Antibody

View all (14) TIRAP antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-116050

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human TIRAP(Accession P58753), corresponding to amino acid residues G201-S221.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2900684

Product Specific Information

Antibody detects endogenous levels of total TIRAP.

Target Information

Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as TIRAP and MyD88 to activate various kinases and transcription factors. In TIRAP-deficient mice, TLR signaling in response to TLR2 ligands (using either TLR1 and TLR6 as co-receptors) is totally abolished, suggesting that MyD88 and TIRAP work together and are both required for TLR2 signaling. Furthermore, these mice are also resistant to the toxic effects of LPS and show defects in NF-βB and MAP kinase activation, suggesting that TIRAP is also involed in TLR4 signaling.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: adapter protein wyatt; Adaptor protein Wyatt; FLJ42305; HGNC:17192; MyD88 adapter-like protein; MyD88-2; OTTHUMP00000179130; TIR domain-containing adapter protein; toll-interleukin 1 receptor (TIR) domain containing adaptor protein; Toll-like receptor adaptor protein; Toll/interleukin-1 receptor domain-containing adapter protein

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Gene Aliases: BACTS1; MAL; MyD88-2; TIRAP; wyatt

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UniProt ID: (Human) P58753

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Entrez Gene ID: (Human) 114609

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Function(s)
protein kinase C binding protein binding phosphatidylinositol-4,5-bisphosphate binding protein binding, bridging Toll-like receptor 4 binding Toll-like receptor 2 binding protein homodimerization activity protein heterodimerization activity
Process(es)
MyD88-dependent toll-like receptor signaling pathway inflammatory response cell surface receptor signaling pathway activation of NF-kappaB-inducing kinase activity myeloid cell differentiation positive regulation of B cell proliferation response to lipopolysaccharide regulation of interferon-beta production positive regulation of interleukin-12 production positive regulation of interleukin-15 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production positive regulation of toll-like receptor 2 signaling pathway positive regulation of toll-like receptor 3 signaling pathway toll-like receptor 4 signaling pathway positive regulation of toll-like receptor 4 signaling pathway TIRAP-dependent toll-like receptor 4 signaling pathway positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of growth of symbiont in host innate immune response regulation of innate immune response positive regulation of interleukin-6 biosynthetic process positive regulation of JNK cascade defense response to Gram-positive bacterium positive regulation of NF-kappaB transcription factor activity positive regulation of ERK1 and ERK2 cascade 3'-UTR-mediated mRNA stabilization cellular response to bacterial lipopeptide cellular response to lipoteichoic acid positive regulation of neutrophil chemotaxis positive regulation of protein homodimerization activity positive regulation of chemokine (C-X-C motif) ligand 1 production positive regulation of chemokine (C-X-C motif) ligand 2 production
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