Invitrogen

TIRAP Recombinant Rabbit Monoclonal Antibody (9T1A8)

View all (14) TIRAP antibodies

Promotion

View available promotion(s)

Promo code: {{promo.promoCode}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-38196

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

9T1A8

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human TIRAP (P58753)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.02 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2898113

Product Specific Information

Positive Samples: 293T, HepG2, THP-1, Mouse brain, Rat spleen, Rat thymus

Immunogen sequence: MASSTSLPAP GSRPKKPLGK MADWFRQTLL KKPKKRPNSP ESTSSDASQP TSQDSPLPPS LSSVTSPSLP PTHASDSGSS RWSKDYDVCV CHSEEDLVAA

Target Information

Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as TIRAP and MyD88 to activate various kinases and transcription factors. In TIRAP-deficient mice, TLR signaling in response to TLR2 ligands (using either TLR1 and TLR6 as co-receptors) is totally abolished, suggesting that MyD88 and TIRAP work together and are both required for TLR2 signaling. Furthermore, these mice are also resistant to the toxic effects of LPS and show defects in NF-βB and MAP kinase activation, suggesting that TIRAP is also involed in TLR4 signaling.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: adapter protein wyatt; Adaptor protein Wyatt; FLJ42305; HGNC:17192; MyD88 adapter-like protein; MyD88-2; OTTHUMP00000179130; TIR domain-containing adapter protein; toll-interleukin 1 receptor (TIR) domain containing adaptor protein; toll-interleukin 1 receptor (TIR) domain-containing adaptor protein; Toll-like receptor 4 adaptor protein; Toll-like receptor adaptor protein; Toll/interleukin-1 receptor domain-containing adapter protein

View more View less

Gene Aliases: AA407980; BACTS1; C130027E04Rik; MAL; MyD88-2; TIRAP; Tlr4ap; Wyatt

View more View less

UniProt ID: (Human) P58753, (Mouse) Q99JY1

View more View less

Entrez Gene ID: (Human) 114609, (Mouse) 117149, (Rat) 680127

View more View less

Function(s)
protein kinase C binding protein binding phosphatidylinositol-4,5-bisphosphate binding protein binding, bridging Toll-like receptor 4 binding Toll-like receptor 2 binding protein homodimerization activity protein heterodimerization activity molecular_function
Process(es)
immune system process inflammatory response signal transduction cell surface receptor signaling pathway I-kappaB kinase/NF-kappaB signaling activation of JUN kinase activity response to bacterium myeloid cell differentiation positive regulation of B cell proliferation response to lipopolysaccharide regulation of interferon-beta production regulation of interleukin-15 production positive regulation of interleukin-12 production positive regulation of interleukin-15 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production positive regulation of toll-like receptor 2 signaling pathway positive regulation of toll-like receptor 3 signaling pathway positive regulation of toll-like receptor 4 signaling pathway toll-like receptor 5 signaling pathway TIRAP-dependent toll-like receptor 4 signaling pathway positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of growth of symbiont in host innate immune response regulation of innate immune response positive regulation of innate immune response positive regulation of interleukin-6 biosynthetic process positive regulation of JNK cascade defense response to Gram-positive bacterium positive regulation of NF-kappaB transcription factor activity positive regulation of ERK1 and ERK2 cascade interleukin-1-mediated signaling pathway 3'-UTR-mediated mRNA stabilization cellular response to bacterial lipopeptide cellular response to lipoteichoic acid positive regulation of neutrophil chemotaxis positive regulation of protein homodimerization activity positive regulation of chemokine (C-X-C motif) ligand 1 production positive regulation of chemokine (C-X-C motif) ligand 2 production MyD88-dependent toll-like receptor signaling pathway activation of NF-kappaB-inducing kinase activity toll-like receptor 4 signaling pathway biological_process
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support