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Invitrogen
TIS11D Polyclonal Antibody
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FIGURE: 1 / 2
TIS11D Antibody (PA5-36248) in WB
Western blot analysis of TIS11D in Lane 1: PC12 whole cell lysate (40 µg), Lane 2: HCT116 whole cell lysate (40 µg), Lane 3: CT26 whole cell lysate (40 µg), Lane 4: A375 whole cell lysate (40 µg), Lane 5: Myla2059 whole cell lysate (40 µg). Samples were incubated with TIS11D polyclonal antibody (Product # PA5-36248) at a dilution of 1:500.
Product Details
PA5-36248
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 200-250 of human TIS11D
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2553439
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 40 kDa.
Purity is >95% by SDS-PAGE.
Target Information
TIS11D, also known as ZFP36LA (zinc finger protein 36, C3H type-like 2), BRF2 (butyrate response factor 2), ERF2 or RNF162C, is a 494 amino acid protein that localizes to the nucleus and contains two CSH1-type zinc fingers. Belonging to the TIS11 family of early response proteins, TIS11D is thought to function as a nuclear transcription factor that binds to 5'UUAUUUAUUU-3' core RNA sequences and may regulate growth factor-induced cellular responses. The gene encoding TIS11D maps to human chromosome 2, which houses over 1, 400 genes and comprises nearly 8% of the human genome. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene, while the lipid metabolic disorder sitosterolemia is associated with defects in the ABCG5 and ABCG8 genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Butyrate response factor 2; EGF-response factor 2; ERF-2; mRNA decay activator protein ZFP36L2; Protein TIS11D; TISD; TPA-induced sequence 11d; ZFP36 ring finger protein-like 2; ZFP36-like 2; zinc finger protein 36, C3H type-like 1; zinc finger protein 36, C3H type-like 2; zinc finger protein 36, C3H type-like 2-like; Zinc finger protein 36, C3H1 type-like 2; zinc finger protein, C3H type, 36-like 2
Gene Aliases: BRF2; ERF-2; ERF2; RNF162C; TIS11D; ZFP36L2
UniProt ID: (Human) P47974, (Mouse) P23949
Entrez Gene ID: (Human) 678, (Mouse) 12193, (Rat) 298765
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
regulation of transcription, DNA-templated
mRNA catabolic process
cell proliferation
response to wounding
hemopoiesis
T cell differentiation in thymus
somatic stem cell population maintenance
regulation of mRNA stability
cellular response to fibroblast growth factor stimulus
negative regulation of fat cell differentiation
somatic stem cell division
definitive hemopoiesis
3'-UTR-mediated mRNA destabilization
ERK1 and ERK2 cascade
cellular response to tumor necrosis factor
cellular response to epidermal growth factor stimulus
cellular response to glucocorticoid stimulus
cellular response to transforming growth factor beta stimulus
cellular response to granulocyte macrophage colony-stimulating factor stimulus
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
cellular response to phorbol 13-acetate 12-myristate
negative regulation of stem cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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