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Product Details
PA5-95331
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E.coli-derived human TK1 recombinant protein (Position: S2-N234).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2807134
Product Specific Information
Human TK1 shares 87.1% and 91.7% amino acid (aa) sequence identity with mouse and rat TK1, respectively.
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: HELA whole cell, SMMC whole cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Target Information
Thymidine Kinase (TK1) is a highly conserved phosphotransferase that is present in most living cells. Thymidine Kinase catalyzes the phosphorylation reaction: deoxythymidine + ATP = deoxythymidine 5'-phosphate + ADP; it is thus involved in the reaction chain to introduce deoxythymidine into the DNA. Thymidine kinase is required for the action of many antiviral drugs, such as azidothymidine (AZT), and is also used to select hybridoma cell lines in the production of monoclonal antibodies. Thymidine Kinase has many clinical applications as it is only present in anticipation of cell division.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EC 2.7.1.21; KITH; thymidine kinase 1 soluble isoform; thymidine kinase 1, soluble; Thymidine kinase, cytosolic; thymidine kinase-1
Gene Aliases: TK1; TK2
UniProt ID: (Human) P04183
Entrez Gene ID: (Human) 7083
liver development
nucleobase-containing compound metabolic process
DNA metabolic process
deoxyribonucleoside monophosphate biosynthetic process
nucleotide biosynthetic process
response to toxic substance
skeletal muscle cell proliferation
phosphorylation
response to nutrient levels
pyrimidine nucleoside salvage
thymidine metabolic process
response to copper ion
digestive tract development
protein homotetramerization
response to cortisol
fetal process involved in parturition
DNA biosynthetic process
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