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Progen
TKTL1 Monoclonal Antibody (VU-7H2-G5-C1)
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Product Details
610175PROGEN
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
VU-7H2-G5-C1
Immunogen
Hplc Purified Peptide From Tktl1
Conjugate
Form
Lyophilized
Concentration
0.05 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 0.5% BSA
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute lyophilized product with 1 mL distilled water.
Expression studies on transketolase-like-1 show that the protein is found in aggressive tumors. The detection of TKTL1 is furthermore correlated with poor patient prognosis and metastasis. Transketolase dependent reactions regulate the non-oxidative part of the pentose-phosphate-pathway (PPP) in glucose metabolism. This pathway generates NADPH and pentose phosphates. The latter are important for nucleic acid metabolism. Beside the ubiquitous transketolase (TKT) other transketolase-like proteins exist. Transketolase-like 1 (TKTL1) is a protein with a 38 amino acid deletion when compared to TKT. TKTL1 expression has been shown in tumors of different entities. Inhibition of TKTL1 expression by RNA interference results in reduced growth of tumor cells, while overexpression of TKTL1 promotes cell proliferation. Recent publications suggest an important role of TKTL1 in the metabolism of tumor cells. In colorectal tumors nuclear as well as cytoplasmic localization has been described.Reactivity on cultured cell lines: THP-1.
Target Information
Strong TKTL1 protein expression has been correlated with a certain type of glucose metabolism (aerobic glycolysis; Warburg effect) and to cells which are affected by chronic complications of diabetic patients. In colon and urothelial carcinomas, expression at the protein level is correlated with invasiveness of tumors and poor patient survival.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: TK 2; Transketolase 2; transketolase-2; transketolase-like 1; Transketolase-like protein 1; Transketolase-related protein
Gene Aliases: TKR; TKT2; TKTL1
UniProt ID: (Human) P51854
Entrez Gene ID: (Human) 8277
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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