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OriGene
TLK2 Monoclonal Antibody (OTI2D10), TrueMAB™
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FIGURE: 1 / 10
TLK2 Antibody (CF805536) in IHC (P)
Immunohistochemical staining of paraffin-embedded human endometrium tissue within the normal limits using anti-TLK2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA805536)(1:150
Product Details
CF805536
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI2D10
Immunogen
Human recombinant protein fragment corresponding to amino acids 1-296 of human TLK2 produced in E.coli.
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
TLK2 or Tousled-like kinase 2, is a nuclear serine/threonine kinases that is thought to be involved in the regulation of chromatin assembly. In addition, TLK2 is also involved in other cellular processes such as intracellular signaling cascade, protein amino acid phosphorylation, cell cycle, chromatin modification and in response to DNA damage stimulus. TLK2 displays maximal activity during S phase of the cell cycle where it appears to be regulated by cell-cycle-dependent phosphorylation. Inhibition of DNA replication causes a rapid loss of TLK2 activity, indicating that TLK2 function is tightly linked to ongoing DNA replication. The TLK2 enzyme is cell-cycle regulated, with maximal activity in S-phase. It is inactivated by phosphorylation at Ser-750, potentially by CHK1. TLK2 heterodimerizes with TLK1. This nuclear protein is widely expressed, with presence in fetal placenta, liver, kidney, pancreas, heart and skeletal muscle tissues, and in several adult cell lines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HsHPK; PKU-alpha; Serine/threonine-protein kinase tousled-like 2; Tousled-like kinase 2
Gene Aliases: HsHPK; PKU-ALPHA; TLK2
UniProt ID: (Human) Q86UE8
Entrez Gene ID: (Human) 11011
regulation of chromatin assembly or disassembly
protein phosphorylation
cellular response to DNA damage stimulus
cell cycle
chromosome segregation
negative regulation of autophagy
covalent chromatin modification
peptidyl-serine phosphorylation
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
intracellular signal transduction
cellular response to gamma radiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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