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Product Details
H00007094-M80A
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgM, kappa
Class
Monoclonal
Type
Antibody
Clone
2B11
Immunogen
TLN1 (AAH42923.1, 86 a.a. approximately 403 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Storage buffer
ascites
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: RPLKIRMLDG TVKTIMVDDS KTVTDMLMTI CARIGITNHD EYSLVRELME EKKEEITGTL RKDKTLLRDE KKMEKLKQKL HTDDELNWLD HGRTLREQGV EEHETLLLRR KFFYSDQNVD SRDPVQLNLL YVQARDDILN GSHPVSFDKA CEFAGFQCQI QFGPHNEQKH KAGFLDLKDF LPKEYVKQKG ERKIFQAHKN CGQMSEIEAK VRYVKLARSL KTYGVSFFLV KEKMKGKNKL VPRLLGITKE CVMRVDEKTK EVIQEWNLTN IKRWAASPKS FTLDFGDYQD GYYSVQTTEG EQIAQLIAGY IDIILKKK
Target Information
Talin, a multifunctional constituent of cell-substratum attachment sites, is a high molecular weight protein (225-235 kDa) found in variety of tissues and cell types. It is localized at a subset of adherens junctions, specialized cell-cell and cell-matrix associations that are characterized by the presence of filamentous actin at the cytoplasmic face of the junctional complex. In cultured cells, talin is absent from cell-cell junctions and found predominantly at adhesion plaques and in fibrillar streaks underlying cell surface fibronectin. Talin interacts with at least two other proteins that are localized at adhesion plaques, vinculin and integrin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Talin-1
Gene Aliases: ILWEQ; KIAA1027; TLN; TLN1
UniProt ID: (Human) Q9Y490
Entrez Gene ID: (Human) 7094
platelet degranulation
movement of cell or subcellular component
muscle contraction
cytoskeletal anchoring at plasma membrane
cell-cell junction assembly
cell-substrate junction assembly
viral process
cortical actin cytoskeleton organization
IRE1-mediated unfolded protein response
platelet aggregation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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