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Invitrogen
TLR1 Monoclonal Antibody (GD2.F4), FITC
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Product Details
MA1-40168
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
GD2.F4
Immunogen
Human TLR1.
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
0.1 mg/mL
Purification
Protein G
Storage buffer
PBS with 1% BSA
Contains
0.02% sodium azide
Storage conditions
4°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_1087873
Product Specific Information
MA1-40168 detects TLR1 from human samples.
The MA1-40168 immunogen is human TLR1.
Positive control: HeLa cells transfected with TLR1 mRNA; Negative control: Mock transfected HeLa cells.
Target Information
TLR1 protein is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. The Toll-like receptor (TLR) family in mammals are comprised of a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and an IL-1 receptor motif in the cytoplasmic domain. The TLRs could constitute an important and unrecognized component of innate immunity in humans. In mice, TLR1 interacts with TLR2 and co-expression of TLR1 and TLR2 enhance the NF-kappaB activation in response to a synthetic lipopeptide. They recognize the lipid configuration of the native mycobacterial lipoprotein as well as several tri-acylated lipopeptides. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for the TLR1 gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD281; TIL; Toll-like receptor 1; Toll/interleukin-1 receptor-like protein
Gene Aliases: CD281; KIAA0012; rsc786; TIL; TIL. LPRS5; TLR1
UniProt ID: (Human) Q15399
Entrez Gene ID: (Human) 7096
toll-like receptor signaling pathway
MyD88-dependent toll-like receptor signaling pathway
inflammatory response
immune response
signal transduction
toll-like receptor 1 signaling pathway
toll-like receptor TLR1:TLR2 signaling pathway
macrophage activation
detection of triacyl bacterial lipopeptide
positive regulation of tumor necrosis factor biosynthetic process
defense response to bacterium
innate immune response
positive regulation of interleukin-6 biosynthetic process
regulation of cytokine secretion
cellular response to triacyl bacterial lipopeptide
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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