Proteintech

TLR6 Polyclonal Antibody

FIGURE: 1 / 5

TLR6 Antibody (22240-1-AP) in WB

Mouse thymus tissue were subjected to SDS PAGE followed by western blot with 22240-1-AP (TLR6 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

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Product Details

22240-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 6 publications 6 publications

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TLR6 Fusion Protein Ag17686 (143-383 aa encoded by BC111755)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.36 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: GNLSQLNFL GLSAMKLQKL DLLPIAHLHL SYILLDLRNY YIKENETESL QILNAKTLHL VFHPTSLFAI QVNISVNTLG CLQLTNIKLN DDNCQVFIKF LSELTRGPTL LNFTLNHIET TWKCLVRVFQ FLWPKPVEYL NIYNLTIIES IREEDFTYSK TTLKALTIEH ITNQVFLFSQ TALYTVFSEM NIMMLTISDT PFIHMLCPHA PSTFKFLNFT QNVFTDSIFE KCSTLVKLET LI (143-383 aa encoded by BC111755)

Target Information

TLR6 (Toll-like receptor 6) is a member of the toll-like receptor family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved and share structural and functional similarities. TLRs recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR6 functionally interacts with TLR2 to mediate cellular response to bacterial lipoproteins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Identification and immunological evaluation of novel TLR2 agonists through structural optimization of Diprovocim.

European journal of medicinal chemistry

Wang X,Wang Y,Zhu Y,Lei X,Zhang M,Li Y

Mon Dec 05 00:00:00 UTC 2022

Biomimetic Nanomedicine-Triggered in Situ Vaccination for Innate and Adaptive Immunity Activations for Bacterial Osteomyelitis Treatment.

ACS nano

Lin H,Yang C,Luo Y,Ge M,Shen H,Zhang X,Shi J

Tue Apr 26 00:00:00 UTC 2022

Design, Synthesis, and Structure-Activity Relationship of N-Aryl-N'-(thiophen-2-yl)thiourea Derivatives as Novel and Specific Human TLR1/2 Agonists for Potential Cancer Immunotherapy.

Journal of medicinal chemistry

Chen Z,Zhang L,Yang J,Zheng L,Hu F,Duan S,Nandakumar KS,Liu S,Yin H,Cheng K

Thu Jun 10 00:00:00 UTC 2021

HBeAg mediates inflammatory functions of macrophages by TLR2 contributing to hepatic fibrosis.

BMC medicine

Xie X,Lv H,Liu C,Su X,Yu Z,Song S,Bian H,Tian M,Qin C,Qi J,Zhu Q

Fri Oct 15 00:00:00 UTC 2021

Pyridoxal-5'-Phosphate Promotes Immunomodulatory Function of Adipose-Derived Mesenchymal Stem Cells through Indoleamine 2,3-Dioxygenase-1 and TLR4/NF-κB Pathway.

Stem cells international

Li C,Huang J,Zhu H,Shi Q,Li D,Ju X

Thu Oct 01 00:00:00 UTC 2020

Structure-activity relationship study and biological evaluation of SAC-Garlic acid conjugates as novel anti-inflammatory agents.

European journal of medicinal chemistry

Bi J,Wang W,Du J,Chen K,Cheng K

Tue Oct 01 00:00:00 UTC 2019

Toll-like receptor 6 V327M polymorphism is associated with an increased risk of Klebsiella pneumoniae infection.

The Pediatric infectious disease journal

Yang H,Zhang X,Geng J,Zheng Z,Fu Q

Sat Nov 01 00:00:00 UTC 2014

Toll-like receptor 6 V327M polymorphism is associated with an increased risk of Klebsiella pneumoniae infection.

The Pediatric infectious disease journal

Yang H,Zhang X,Geng J,Zheng Z,Fu Q

Sat Nov 01 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: CD antigen 286; CD286; Toll-like receptor 6

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Gene Aliases: CD286; TLR6

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UniProt ID: (Human) Q9Y2C9, (Mouse) Q9EPW9

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Entrez Gene ID: (Human) 10333, (Mouse) 21899

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Function(s)

receptor activity transmembrane signaling receptor activity protein binding Toll-like receptor 2 binding lipopeptide binding diacyl lipopeptide binding protein heterodimerization activity

Process(es)

microglial cell activation toll-like receptor signaling pathway immune system process MyD88-dependent toll-like receptor signaling pathway inflammatory response immune response signal transduction response to bacterial lipoprotein toll-like receptor 6 signaling pathway T-helper 1 type immune response detection of diacyl bacterial lipopeptide positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of JUN kinase activity positive regulation of interleukin-12 biosynthetic process innate immune response positive regulation of interleukin-6 biosynthetic process nitric oxide metabolic process regulation of cytokine secretion cellular response to diacyl bacterial lipopeptide activation of NF-kappaB-inducing kinase activity toll-like receptor TLR6:TLR2 signaling pathway defense response to bacterium interleukin-1 beta secretion positive regulation of NLRP3 inflammasome complex assembly

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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TLR6 Polyclonal Antibody

TLR6 Antibody (22240-1-AP) in WB

Product Details

22240-1-AP

Western Blot (WB)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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