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TLR8 Antibody (MA5-16194) in Flow
Flow cytometry of TLR8 in Ramos cells. Samples were incubated in TLR8 monoclonal antibody (Product # MA5-16194) using a dilution of 2 µg. Shaded histogram represents Ramos cells without antibody; green represents isotype control; red represents anti-TLR8 antibody.
Product Details
MA5-16194
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rabbit
Published species
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
44C143
Immunogen
A KLH-conjugated synthetic peptide of human TLR8, within amino acids 750-850.
Conjugate
Excitation/Emission Max
565/576 nm
View spectra
Form
Liquid
Concentration
0.28 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
4°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2537713
Target Information
The TLR8 protein is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. The TLR8 gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD antigen 288; CD288; Toll-like receptor 8
Gene Aliases: CD288; TLR8; UNQ249/PRO286
UniProt ID: (Human) Q9NR97, (Mouse) P58682
Entrez Gene ID: (Human) 51311, (Mouse) 170744
microglial cell activation
regulation of protein phosphorylation
toll-like receptor signaling pathway
immune system process
MyD88-dependent toll-like receptor signaling pathway
inflammatory response
signal transduction
I-kappaB kinase/NF-kappaB signaling
response to virus
toll-like receptor 8 signaling pathway
positive regulation of interferon-gamma biosynthetic process
innate immune response
positive regulation of innate immune response
positive regulation of interferon-alpha biosynthetic process
positive regulation of interferon-beta biosynthetic process
positive regulation of interleukin-8 biosynthetic process
regulation of cytokine secretion
defense response to virus
immunoglobulin mediated immune response
toll-like receptor 9 signaling pathway
cellular response to mechanical stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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