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TLR8 Antibody (CF810174) in IHC (P)
Immunohistochemical staining of paraffin-embedded Carcinoma of Human spleen tissue within the normal limits using anti-TLR8 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA810174))
(1:2000).
(1:2000).
Product Details
CF810174
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
OTI4F3
Immunogen
Human recombinant protein fragment corresponding to amino acids 32-153 of human TLR8 produced in E.coli.
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
The TLR8 protein is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. The TLR8 gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD antigen 288; CD288; Toll-like receptor 8
Gene Aliases: CD288; TLR8; UNQ249/PRO286
UniProt ID: (Human) Q9NR97
Entrez Gene ID: (Human) 51311
microglial cell activation
regulation of protein phosphorylation
toll-like receptor signaling pathway
MyD88-dependent toll-like receptor signaling pathway
inflammatory response
I-kappaB kinase/NF-kappaB signaling
response to virus
immunoglobulin mediated immune response
toll-like receptor 8 signaling pathway
toll-like receptor 9 signaling pathway
positive regulation of interferon-gamma biosynthetic process
innate immune response
positive regulation of innate immune response
positive regulation of interferon-alpha biosynthetic process
positive regulation of interferon-beta biosynthetic process
positive regulation of interleukin-8 biosynthetic process
regulation of cytokine secretion
defense response to virus
cellular response to mechanical stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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