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Proteintech
TLX1 Polyclonal Antibody
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Product Details
26877-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TLX1 Fusion Protein Ag21899 (31-123 aa encoded by BC130530)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: GGCMGPASR LQDGEYGLGC LVGGAYTYGG GGSAAATGAG GAGAYGTGGP GGPGGPAGGG GACSMGPLTG SYNVNMALAG GPGPGGGGGS SGGA (31-123 aa encoded by BC130530)
Target Information
The Hox proteins play a role in patterns of embryonic development and cellular differentiation by regulating downstream target genes. TLX1, also called homeobox11 (HOX11), as it is located outside of the four mammalian Hox clusters, is a DNA-binding nuclear transcription factor. TLX1 encodes a homeobox-domain containing protein and is containing a glycine and proline-rich amino terminus. TLX1 is required for maintenance of the developing spleen and cell survival. TLX1 is highly expressed in T-cell leukemia and lymphoid neoplasias as a result of translocation. TLX1-deficient mice have no spleen.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: homeo box-11 (T-cell leukemia-3 associated breakpoint, homologous to Drosophila Notch); Homeobox protein Hox-11; homeobox TLX-1; MGC163402; Proto-oncogene TCL-3; T-cell leukemia homeobox protein 1; T-cell leukemia, homeobox 1; T-cell leukemia/lymphoma protein 3
Gene Aliases: Hox-11; HOX11; TCL3; TLX1
UniProt ID: (Human) P31314
Entrez Gene ID: (Human) 3195, (Mouse) 21908
transcription from RNA polymerase II promoter
multicellular organism development
positive regulation of transcription from RNA polymerase II promoter
central nervous system development
positive regulation of cell proliferation
neuron differentiation
cell fate commitment
lymph node development
spleen development
organ formation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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