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Invitrogen
TLX1 Polyclonal Antibody
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FIGURE: 1 / 1
TLX1 Antibody (PA5-88816) in WB
Western blot analysis of TLX1 in extracts of various cell lines. Samples were incubated with TLX1 Polyclonal antibody (Product # PA5-88816) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Product Details
PA5-88816
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human TLX1 (NP_0011824461)
Conjugate
Form
Liquid
Concentration
0.46 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2805149
Product Specific Information
Immunogen sequence: MEHLGPHHLH PGHAEPISFG IDQILNSPDQ GGCMGPASRL QDGEYGLGCL VGGAYTYGGG GSAAATGAGG AGAYGTGGPG GPGGPAGGGG ACSMGPLTGS YNVNMALAGG PGPGGGGGSS GGAGALSAAG VIRVPAHRPL AGAVAHPQPL ATGLPTVPSV PAMPGVNNLT GLTFPWMESN RRYTKDRFTG; Positive Samples: Jurkat, K562, Mouse spleen, Rat spleen; Cellular Location: Nucleus
Target Information
The Hox proteins play a role in patterns of embryonic development and cellular differentiation by regulating downstream target genes. TLX1, also called homeobox11 (HOX11), as it is located outside of the four mammalian Hox clusters, is a DNA-binding nuclear transcription factor. TLX1 encodes a homeobox-domain containing protein and is containing a glycine and proline-rich amino terminus. TLX1 is required for maintenance of the developing spleen and cell survival. TLX1 is highly expressed in T-cell leukemia and lymphoid neoplasias as a result of translocation. TLX1-deficient mice have no spleen.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: homeo box-11 (T-cell leukemia-3 associated breakpoint, homologous to Drosophila Notch); Homeobox protein Hox-11; homeobox TLX-1; MGC163402; Proto-oncogene TCL-3; T-cell leukemia homeobox protein 1; T-cell leukemia, homeobox 1; T-cell leukemia/lymphoma protein 3
Gene Aliases: Hox-11; HOX11; RGD1563655; TCL3; TLX1
UniProt ID: (Human) P31314
Entrez Gene ID: (Human) 3195, (Rat) 499361, (Mouse) 21908
transcription from RNA polymerase II promoter
multicellular organism development
positive regulation of transcription from RNA polymerase II promoter
central nervous system development
biological_process
positive regulation of cell proliferation
neuron differentiation
cell fate commitment
spleen development
organ formation
lymph node development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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