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Invitrogen
TLX3 Polyclonal Antibody
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Product Details
PA5-34555
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 16 amino acid peptide near the amino terminus of human TLX3
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2551907
Product Specific Information
A suggested positive control is human spleen tissue lysate.
PA5-34555 can be used with blocking peptide PEP-1598.
Target Information
The Hox proteins play a role in patterns of embryonic development and cellular differentiation by regulating downstream target genes. TLX3, also known as homeobox11-like1 (HOX11L2), is a DNA-binding nuclear transcription factor that is expressed in a subset of the primary sensory nervous system. TLX3, along with the related TLX1, is a selector transcription factor that promotes an excitatory glutamatergic neuronal phenotype over an inhibitory GABAergic phenotype opposing LBX1 signals during dorsal spinal cord development. Chromosomal translocations of the TLX3 gene have been shown to result in some forms of T-cell acute lymphoblastic leukemia (T-ALL).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: homeo box 11-like 2; homeobox 11-like 2; Homeobox protein Hox-11L2; Homeobox TLX-3; Respiratory neuron homeobox protein; T-cell leukemia homeobox protein 3; T-cell leukemia, homeobox 3
Gene Aliases: HOX11L2; RGD1564190; RNX; Tlx1l2; TLX3
UniProt ID: (Human) O43711, (Mouse) O55144
Entrez Gene ID: (Human) 30012, (Mouse) 27140, (Rat) 497881
cell fate specification
neuron migration
regulation of respiratory gaseous exchange by neurological system process
regulation of transcription, DNA-templated
multicellular organism development
central nervous system development
respiratory gaseous exchange
neuron differentiation
negative regulation of neuron differentiation
neuron fate specification
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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