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TLX3 Antibody (PA5-85574) in IHC (P)
TLX3 Polyclonal Antibody detects TLX3 protein at nucleus on mouse fore brain by immunohistochemical analysis. Sample: Paraffin-embedded mouse fore brain. TLX3 Polyclonal Antibody (Product # PA5-85574) dilution: 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
Product Details
PA5-85574
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human TLX3. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2792714
Product Specific Information
Keep as concentrated solution.
Predicted reactivity: Mouse (100%), Xenopus laevis (100%), Chicken (100%), Bovine (100%).
Positive Control: SK-N-SH, IMR32, SK-N-AS.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The Hox proteins play a role in patterns of embryonic development and cellular differentiation by regulating downstream target genes. TLX3, also known as homeobox11-like1 (HOX11L2), is a DNA-binding nuclear transcription factor that is expressed in a subset of the primary sensory nervous system. TLX3, along with the related TLX1, is a selector transcription factor that promotes an excitatory glutamatergic neuronal phenotype over an inhibitory GABAergic phenotype opposing LBX1 signals during dorsal spinal cord development. Chromosomal translocations of the TLX3 gene have been shown to result in some forms of T-cell acute lymphoblastic leukemia (T-ALL).
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: homeo box 11-like 2; homeobox 11-like 2; Homeobox protein Hox-11L2; Homeobox TLX-3; Respiratory neuron homeobox protein; T-cell leukemia homeobox protein 3; T-cell leukemia, homeobox 3
Gene Aliases: HOX11L2; RNX; Tlx1l2; TLX3
UniProt ID: (Human) O43711, (Mouse) O55144
Entrez Gene ID: (Human) 30012, (Mouse) 27140
cell fate specification
neuron migration
regulation of respiratory gaseous exchange by neurological system process
regulation of transcription, DNA-templated
multicellular organism development
central nervous system development
respiratory gaseous exchange
neuron differentiation
negative regulation of neuron differentiation
neuron fate specification
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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