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Invitrogen
TM6SF2 Polyclonal Antibody
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FIGURE: 1 / 1
TM6SF2 Antibody (PA5-143888) in WB
Western blot analysis of TM6SF2 using TM6SF2 antibody (Product # PA5-143888). Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 30 µg of sample under reducing conditions. Lane 1: rat liver tissue lysates; Lane 2: rat RH35 whole cell lysates; Lane 3: mouse liver tissue lysates; Lane 3: mouse small intestine tissue lysates. After electrophoresis, proteins were transferred to a nitrocellulose membrane at 150 mA for 50-90 minutes. Blocke... View More
Product Details
PA5-143888
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E.coli-derived human TM6SF2 recombinant protein (Position: D78-H377).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3075102
Product Specific Information
Adding 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Positive Control - WB: rat liver tissue, rat RH35 whole cell, mouse liver tissue, mouse small intestine tissue .|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Target Information
The TM6SF2 gene encodes transmembrane 6 superfamily member 2, a protein implicated in lipid metabolism and liver function. TM6SF2 is predominantly expressed in the liver and plays a crucial role in the regulation of lipid homeostasis, affecting the secretion of triglycerides and cholesterol. Genetic variations in TM6SF2, particularly the E167K polymorphism, have been associated with non-alcoholic fatty liver disease (NAFLD) and cardiovascular diseases. This variant influences lipid metabolism by altering the balance between lipid storage and secretion, contributing to hepatic steatosis and the progression of liver disease. Additionally, TM6SF2 mutations impact the risk of atherosclerosis due to their effects on lipid profiles, highlighting its significance in metabolic diseases. Research into TM6SF2 continues to uncover its roles in regulating lipid transport and metabolism, making it a potential target for therapeutic strategies addressing liver and cardiovascular health.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Transmembrane 6 superfamily member 2
Gene Aliases: TM6SF2
UniProt ID: (Human) Q9BZW4, (Mouse) Q8R1J1, (Rat) B0BNG2
Entrez Gene ID: (Human) 53345, (Mouse) 107770, (Rat) 689029
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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