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Invitrogen
TMED2 Polyclonal Antibody
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Product Details
PA5-120563
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 60-170 of human TMED2 (NP_006806.1).
Conjugate
Form
Liquid
Concentration
2.56 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2914135
Product Specific Information
Positive test controls include: U-87MG, HepG2, Mouse liver, Mouse kidney, Rat spleen, Rat lung, Rat liver.
Immunogen sequence: EITGPDNKGI YKGDRESSGK YTFAAHMDGT YKFCFSNRMS TMTPKIVMFT IDIGEAPKGQ DMETEAHQNK LEEMINELAV AMTAVKHEQE YMEVRERIHR AINDNTNSRV V
Target Information
TMED2 is a protein coding gene involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase-activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play a role in the biosynthesis of secreted cargo such as eventual processing.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: coated vesicle membrane protein; COPI-coated vesicle membrane protein p24; Membrane protein p24A; p24; p24 family protein beta-1; p24beta1; RNP21.4; Sid 394; Sid394p; transmembrane emp24 domain trafficking protein 2; Transmembrane emp24 domain-containing protein 2
Gene Aliases: 1110032D12Rik; 1810020N21Rik; p24; P24A; p24b1; p24beta1; RNP24; Sid394; TMED2
UniProt ID: (Human) Q15363, (Rat) Q63524, (Mouse) Q9R0Q3
Entrez Gene ID: (Human) 10959, (Rat) 65165, (Mouse) 56334
neural tube closure
maternal placenta development
heart looping
intracellular protein transport
ER to Golgi vesicle-mediated transport
retrograde vesicle-mediated transport, Golgi to ER
Golgi organization
positive regulation of gene expression
somite rostral/caudal axis specification
negative regulation of GTPase activity
multicellular organism growth
cargo loading into vesicle
post-anal tail morphogenesis
COPI coating of Golgi vesicle
COPII vesicle coating
labyrinthine layer blood vessel development
protein targeting to plasma membrane
in utero embryonic development
somitogenesis
embryonic placenta development
vesicle targeting
embryonic morphogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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