Proteintech

TMEM106B Polyclonal Antibody

TMEM106B Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 9

TMEM106B Antibody (20995-1-AP) in ICC/IF

Immunofluorescent analysis of HeLa cells using 20995-1-AP (TMEM106B antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

TMEM106B Antibody in Immunohistochemistry (Paraffin) (IHC (P))

TMEM106B Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

20995-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 3 publications 3 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TMEM106B Fusion Protein Ag14264 (150-275 aa encoded by BC033901)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.35 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: LNITNNNYY SVEVENITAQ VQFSKTVIGK ARLNNITIIG PLDMKQIDYT VPTVIAEEMS YMYDFCTLIS IKVHNIVLMM QVTVTTTYFG HSEQISQERY QYVDCGRNTT YQLGQSEYLN VLQPQQ (150-275 aa encoded by BC033901)

Target Information

Transmembrane protein 106B (TMEM106B) is a single-pass transmembrane protein that is thought to be a novel risk factor for frontotemporal lobar degeneration (FTLD), a group of clinically, pathologically and genetically heterogeneous disorders associated with atrophy in the frontal lobe and temporal lobe of the brain. The actual role of TMEM106B, and that of the closely related protein TMEM106A are still undetermined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Superresolution live-cell imaging reveals that the localization of TMEM106B to filopodia in oligodendrocytes is compromised by the hypomyelination-related D252N mutation.

Science China. Life sciences

Xing S,Zheng X,Yan H,Mo Y,Duan R,Chen Z,Wang K,Gao K,Chen T,Zhao S,Wang J,Chen L

Tue Aug 01 00:00:00 UTC 2023

Homotypic fibrillization of TMEM106B across diverse neurodegenerative diseases.

Cell

Chang A,Xiang X,Wang J,Lee C,Arakhamia T,Simjanoska M,Wang C,Carlomagno Y,Zhang G,Dhingra S,Thierry M,Perneel J,Heeman B,Forgrave LM,DeTure M,DeMarco ML,Cook CN,Rademakers R,Dickson DW,Petrucelli L,Stowell MHB,Mackenzie IRA,Fitzpatrick AWP

Thu Apr 14 00:00:00 UTC 2022

Construction of ceRNA network to identify the lncRNA and mRNA related to non-small cell lung cancer.

PloS one

Xiao K,Wang Y,Zhou L,Wang J,Wang Y,Tong D,Zhu Z,Jiang J

Mon Dec 06 00:00:00 UTC 2021

TMEM106B, a frontotemporal lobar dementia (FTLD) modifier, associates with FTD-3-linked CHMP2B, a complex of ESCRT-III.

Molecular brain

Jun MH,Han JH,Lee YK,Jang DJ,Kaang BK,Lee JA

Thu Dec 10 00:00:00 UTC 2015

TMEM106B expression is reduced in Alzheimer's disease brains.

Alzheimer's research & therapy

Satoh J,Kino Y,Kawana N,Yamamoto Y,Ishida T,Saito Y,Arima K

Tue Aug 12 00:00:00 UTC 2014

TMEM106B expression is reduced in Alzheimer's disease brains.

Alzheimer's research & therapy

Satoh J,Kino Y,Kawana N,Yamamoto Y,Ishida T,Saito Y,Arima K

Tue Aug 12 00:00:00 UTC 2014

TMEM106B, the risk gene for frontotemporal dementia, is regulated by the microRNA-132/212 cluster and affects progranulin pathways.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Chen-Plotkin AS,Unger TL,Gallagher MD,Bill E,Kwong LK,Volpicelli-Daley L,Busch JI,Akle S,Grossman M,Van Deerlin V,Trojanowski JQ,Lee VM

Wed Aug 15 00:00:00 UTC 2012

TMEM106B, the risk gene for frontotemporal dementia, is regulated by the microRNA-132/212 cluster and affects progranulin pathways.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Chen-Plotkin AS,Unger TL,Gallagher MD,Bill E,Kwong LK,Volpicelli-Daley L,Busch JI,Akle S,Grossman M,Van Deerlin V,Trojanowski JQ,Lee VM

Wed Aug 15 00:00:00 UTC 2012

Bioinformatics

Protein Aliases: Transmembrane protein 106B

View more View less

Gene Aliases: 2310036D22Rik; 5830455K21Rik; 6430519M21Rik; AI428776; AI661344; TMEM106B

View more View less

UniProt ID: (Human) Q9NUM4, (Mouse) Q80X71

View more View less

Entrez Gene ID: (Human) 54664, (Mouse) 71900

View more View less

Function(s)

molecular_function protein binding

Process(es)

transport lysosome localization dendrite morphogenesis lysosome organization lysosomal transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

TMEM106B Polyclonal Antibody

TMEM106B Antibody (20995-1-AP) in ICC/IF

Product Details

20995-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!