Proteintech

TMEM16A/DOG1 Polyclonal Antibody

TMEM16A/DOG1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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TMEM16A/DOG1 Antibody (12652-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded stromal tumor tissue slide using 12652-1-AP ( TMEM16A/DOG1 antibody at dilution of 1:50 (under 40x lens).

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Product Details

12652-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

View 2 publications 2 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TMEM16A/DOG1 Fusion Protein Ag3320 (541-712 aa encoded by BC027590)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.24 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody can recognize isoform1 and isoform2 of human ANO1.

Immunogen sequence: LVYLYMYSK NGTMHGFVNH TLSSFNVSDF QNGTAPNDPL DLGYEVQICR YKDYREPPWS ENKYDISKDF WAVLAARLAF VIVFQNLVMF MSDFVDWVIP DIPKDISQEI HKEKVLMVEL FMREEQDKQQ LLETWMEKER QKDEPPCNHH NTKACPDSLG SPAPSHAYHG GVL (541-712 aa encoded by BC027590)

Target Information

DOG-1, the novel marker, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of kit or PDGFR alpha mutation status.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

ANO1 Reprograms Cholesterol Metabolism and the Tumor Microenvironment to Promote Cancer Metastasis.

Cancer research

Deng CM,Zhang GG,Liu QW,Xu JJ,Liu ZC,Yang J,Xu TY,Li ZG,Zhang F,Li B

Fri Jun 02 00:00:00 UTC 2023

ANO1 Reprograms Cholesterol Metabolism and the Tumor Microenvironment to Promote Cancer Metastasis.

Cancer research

Deng CM,Zhang GG,Liu QW,Xu JJ,Liu ZC,Yang J,Xu TY,Li ZG,Zhang F,Li B

Fri Jun 02 00:00:00 UTC 2023

ANO1 Reprograms Cholesterol Metabolism and the Tumor Microenvironment to Promote Cancer Metastasis.

Cancer research

Deng CM,Zhang GG,Liu QW,Xu JJ,Liu ZC,Yang J,Xu TY,Li ZG,Zhang F,Li B

Fri Jun 02 00:00:00 UTC 2023

ANO1 Reprograms Cholesterol Metabolism and the Tumor Microenvironment to Promote Cancer Metastasis.

Cancer research

Deng CM,Zhang GG,Liu QW,Xu JJ,Liu ZC,Yang J,Xu TY,Li ZG,Zhang F,Li B

Fri Jun 02 00:00:00 UTC 2023

Primary extra-gastrointestinal stromal tumor of retroperitoneum: Clinicopathologic characteristics and prognosis of six cases.

Frontiers in oncology

Lin J,Liao W,Wang J,Li W,Tang X,Li H,Yi X,Lu X,Chen Z,Zhu B,Feng X,Diao D

Sat Mar 11 00:00:00 UTC 2023

miR-128 participates in the pathogenesis of chronic constipation by regulating the p38α/M-CSF inflammatory signaling pathway.

American journal of physiology. Gastrointestinal and liver physiology

Hong Y,Ren X,Liu W,Sun K,Chen B,Liu B,Yu X,Chen Q,Qian Q,Xie X,Jiang C

Fri Oct 01 00:00:00 UTC 2021

Calcium-activated chloride channel is involved in the onset of diarrhea triggered by EGFR tyrosine kinase inhibitor treatment in rats.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Harada Y,Sekine H,Kubota K,Sadatomi D,Iizuka S,Fujitsuka N

Wed Sep 01 00:00:00 UTC 2021

Dual role of Ca²⁺-activated Cl^- channel transmembrane member 16A in lipopolysaccharide-induced intestinal epithelial barrier dysfunction in vitro.

Cell death & disease

Sui J,Zhang C,Fang X,Wang J,Li Y,Wang J,Wang L,Dong J,Zhou Z,Li C,Chen J,Ma T,Chen D

Fri May 29 00:00:00 UTC 2020

Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility.

eLife

Zhang DL,Sun YJ,Ma ML,Wang YJ,Lin H,Li RR,Liang ZL,Gao Y,Yang Z,He DF,Lin A,Mo H,Lu YJ,Li MJ,Kong W,Chung KY,Yi F,Li JY,Qin YY,Li J,Thomsen ARB,Kahsai AW,Chen ZJ,Xu ZG,Liu M,Li D,Yu X,Sun JP

Fri Feb 02 00:00:00 UTC 2018

Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility.

eLife

Zhang DL,Sun YJ,Ma ML,Wang YJ,Lin H,Li RR,Liang ZL,Gao Y,Yang Z,He DF,Lin A,Mo H,Lu YJ,Li MJ,Kong W,Chung KY,Yi F,Li JY,Qin YY,Li J,Thomsen ARB,Kahsai AW,Chen ZJ,Xu ZG,Liu M,Li D,Yu X,Sun JP

Fri Feb 02 00:00:00 UTC 2018

Anoctamin-1 in the juvenile rat urinary bladder.

PloS one

Bijos DA,Drake MJ,Vahabi B

Mon May 18 00:00:00 UTC 2015

Anoctamin-1 in the juvenile rat urinary bladder.

PloS one

Bijos DA,Drake MJ,Vahabi B

Mon May 18 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: anoctamin 1, calcium activated chloride channel; Anoctamin-1; Ca2+-activated Cl- channel; calcium activated chloride channel; Discovered on gastrointestinal stromal tumors protein 1; FLJ10261; oral cancer overexpressed 2; Oral cancer overexpressed protein 2; Transmembrane protein 16A; transmembrane protein 16A (eight membrane-spanning domains); Tumor-amplified and overexpressed sequence 2

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Gene Aliases: ANO1; DOG1; ORAOV2; TAOS2; TMEM16A

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UniProt ID: (Human) Q5XXA6, (Mouse) Q8BHY3

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Entrez Gene ID: (Human) 55107, (Mouse) 101772

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Function(s)

calcium activated cation channel activity intracellular calcium activated chloride channel activity voltage-gated chloride channel activity chloride channel activity protein binding iodide transmembrane transporter activity protein dimerization activity phospholipid scramblase activity protein homodimerization activity protein heterodimerization activity

Process(es)

transport ion transport cation transport chloride transport multicellular organism development regulation of membrane potential trachea development cation transmembrane transport chloride transmembrane transport phospholipase C-activating G-protein coupled receptor signaling pathway iodide transport ion transmembrane transport cellular response to heat positive regulation of insulin secretion involved in cellular response to glucose stimulus detection of temperature stimulus involved in sensory perception of pain regulation of anion transmembrane transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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TMEM16A/DOG1 Polyclonal Antibody

TMEM16A/DOG1 Antibody (12652-1-AP) in IHC (P)

Product Details

12652-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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