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          • Primary Antibodies ›
          • STING Antibodies

          Proteintech

          TMEM173/STING Polyclonal Antibody

          272 References
          View all (93) STING antibodies

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          Datasheet
          Protocols
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          Datasheet
          Protocols
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          Cite TMEM173/STING Polyclonal Antibody

          • Antibody Testing Data (26)
          TMEM173/STING Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.
          TMEM173/STING Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.

          FIGURE: 1 / 26

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          TMEM173/STING Antibody (19851-1-AP) in ICC/IF

          Immunofluorescent analysis of ( -20°C Ethanol ) fixed HepG2 cells using 19851-1-AP (TMEM173/STING antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          TMEM173/STING Antibody in Immunocytochemistry (ICC/IF)
          TMEM173/STING Antibody in Immunocytochemistry (ICC/IF)
          TMEM173/STING Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          TMEM173/STING Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          TMEM173/STING Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          TMEM173/STING Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          TMEM173/STING Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          TMEM173/STING Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          TMEM173/STING Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          TMEM173/STING Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          TMEM173/STING Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          TMEM173/STING Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          TMEM173/STING Antibody in Western Blot (WB)
          TMEM173/STING Antibody in Western Blot (WB)
          TMEM173/STING Antibody in Western Blot (WB)
          TMEM173/STING Antibody in Western Blot (WB)
          TMEM173/STING Antibody in Western Blot (WB)
          TMEM173/STING Antibody in Western Blot (WB)
          TMEM173/STING Antibody in Western Blot (WB)
          TMEM173/STING Antibody in Western Blot (WB)
          TMEM173/STING Antibody in Western Blot (WB)
          TMEM173/STING Antibody in Western Blot (WB)
          TMEM173/STING Antibody in Western Blot (WB)
          TMEM173/STING Antibody in Western Blot (WB)
          TMEM173/STING Antibody in Flow Cytometry (Flow)
          TMEM173/STING Antibody in Immunoprecipitation (IP)

          Product Details

          19851-1-AP

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:2,000
          View 160 publications 160 publications

          Immunohistochemistry (IHC)

          -
          View 34 publications 34 publications

          Immunohistochemistry (Paraffin) (IHC (P))

          1:20-1:200
          -

          Immunocytochemistry (ICC/IF)

          1:50-1:500
          View 61 publications 61 publications

          Flow Cytometry (Flow)

          0.2 µg/1x10^6 cells
          View 3 publications 3 publications

          Immunoprecipitation (IP)

          0.5-4.0 µg
          View 11 publications 11 publications

          Not applicable (N/A)

          -
          View 3 publications 3 publications
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Published species

          Human, Mouse, Pig, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          TMEM173/STING Fusion Protein Ag13921 (174-379 aa encoded by BC047779)
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          0.33 mg/mL

          Purification

          Antigen affinity chromatography

          Storage buffer

          PBS, pH 7.3, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Wet ice (domestic); Dry ice (international)

          Product Specific Information

          Immunogen sequence: ELQARIRTY NQHYNNLLRG AVSQRLYILL PLDCGVPDNL SMADPNIRFL DKLPQQTGDH AGIKDRVYSN SIYELLENGQ RAGTCVLEYA TPLQTLFAMS QYSQAGFSRE DRLEQAKLFC RTLEDILADA PESQNNCRLI AYQEPADDSS FSLSQEVLRH LRQEEKEEVT VGSLKTSAVP STSTMSQEPE LLISGMEKPL PLRTDFS (174-379 aa encoded by BC047779 )

          Target Information

          STING is a 379 amino acid containing signaling protein that acts as an important component of innate immune signaling. This signaling protein is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta) and exert a potent anti-viral state following expression. STING may have translocon function, the translocon possibly being able to influence the induction of type I interferons and is also involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II) thus facilitating the detection of intracellular viral RNA species as well as B-form DNA and mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Generally seen in endoplasmic reticulum membrane, cell membrane and mitochondrion outer membrane, it is ubiquitously expressed in most of tissues.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: endoplasmic reticulum IFN stimulator; Endoplasmic reticulum interferon stimulator; ERIS; hMITA; hSTING; Mediator of IRF3 activation; mitochondrial mediator of IRF3 activation; mitochondrial transmembrane protein 173; MMITA; mSTING; N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner; rSTING; Stimulator of interferon genes protein; tm173; Transmembrane protein 173

          View more View less

          Gene Aliases: 2610307O08Rik; ERIS; hMITA; hSTING; MITA; MPYS; NET23; RGD1562552; SAVI; STING; STING1; TMEM173

          View more View less

          UniProt ID: (Human) Q86WV6, (Mouse) Q3TBT3, (Rat) F1M391

          View more View less

          Entrez Gene ID: (Human) 340061, (Mouse) 72512, (Rat) 498840

          View more View less

          Function(s)
          protein binding transcription factor binding protein kinase binding ubiquitin protein ligase binding cyclic-di-GMP binding identical protein binding protein homodimerization activity cyclic-GMP-AMP binding nucleotide binding
          Process(es)
          activation of innate immune response positive regulation of defense response to virus by host apoptotic process positive regulation of protein binding regulation of type I interferon production positive regulation of type I interferon production interferon-beta production positive regulation of protein import into nucleus, translocation cellular response to interferon-beta positive regulation of transcription factor import into nucleus innate immune response positive regulation of transcription from RNA polymerase II promoter defense response to virus cellular response to exogenous dsRNA cellular response to organic cyclic compound immune system process
          It has to be done as per old AB suggested Products section.
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