Proteintech

TMEM173/STING Monoclonal Antibody (1F1E1)

TMEM173/STING Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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TMEM173/STING Antibody (66680-1-IG) in IHC (P)

Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using 66680-1-IG (TMEM173/STING antibody) at dilution of 1:1000 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

TMEM173/STING Antibody in Western Blot (WB)

Product Image Gallery

Product Details

66680-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:2,000-1:10,000

View 15 publications 15 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:500-1:2,000

Immunocytochemistry (ICC/IF)

View 11 publications 11 publications

Immunoprecipitation (IP)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Rat

Published species

Human, Mouse

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

1F1E1

Immunogen

TMEM173/STING Fusion Protein Ag20363 (174-379 aa encoded by BC047779)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: ELQARIRTY NQHYNNLLRG AVSQRLYILL PLDCGVPDNL SMADPNIRFL DKLPQQTGDH AGIKDRVYSN SIYELLENGQ RAGTCVLEYA TPLQTLFAMS QYSQAGFSRE DRLEQAKLFC RTLEDILADA PESQNNCRLI AYQEPADDSS FSLSQEVLRH LRQEEKEEVT VGSLKTSAVP STSTMSQEPE LLISGMEKPL PLRTDFS (174-379 aa encoded by BC047779 )

Target Information

STING is a 379 amino acid containing signaling protein that acts as an important component of innate immune signaling. This signaling protein is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta) and exert a potent anti-viral state following expression. STING may have translocon function, the translocon possibly being able to influence the induction of type I interferons and is also involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II) thus facilitating the detection of intracellular viral RNA species as well as B-form DNA and mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Generally seen in endoplasmic reticulum membrane, cell membrane and mitochondrion outer membrane, it is ubiquitously expressed in most of tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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Soluble CD4 effectively prevents excessive TLR activation of resident macrophages in the onset of sepsis.

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Glutamylation of an HIV-1 protein inhibits the immune response by hijacking STING.

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Qian G,Zhang Y,Liu Y,Li M,Xin B,Jiang W,Han W,Wang Y,Tang X,Li L,Zhu L,Sun T,Yan B,Zheng Y,Xu J,Ge B,Zhang Z,Yan D

Tue May 30 00:00:00 UTC 2023

NETs Promote Inflammatory Injury by Activating cGAS-STING Pathway in Acute Lung Injury.

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Aβ Induces Neuroinflammation and Microglial M1 Polarization via cGAS-STING-IFITM3 Signaling Pathway in BV-2 Cells.

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Fri Sep 01 00:00:00 UTC 2023

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Sat Jan 01 00:00:00 UTC 2022

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Fri Jul 01 00:00:00 UTC 2022

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Sat Mar 05 00:00:00 UTC 2022

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