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Invitrogen
TMEM18 Polyclonal Antibody
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FIGURE: 1 / 1
TMEM18 Antibody (PA5-116855) in WB
Western blot analysis of TMEM18 in extracts of various cell lines. Samples were incubated with TMEM18 Polyclonal antibody (Product # PA5-116855) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 3 min.
Product Details
PA5-116855
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 40-100 of human TMEM18 (NP_6900472)
Conjugate
Form
Liquid
Concentration
1.33 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2901486
Product Specific Information
Positive Samples: HeLa, A-549, Rat kidney
Immunogen sequence: LLTCLSSRSY RLQIGHFLCL VILVYCAEYI NEAAAMNWRL FSKYQYFDSR GMFISIVFSA P
Target Information
Recent studies have examined how overexpression of certain genes enhances the tropism of neural stem cells (NSCs) for gliomas. Overexpression of Transmembrane protein 18 (TMEM18) provides NSCs and neural precursors an increased migration capacity towards glioblastoma cells in vitro and in the rat brain, while functional inactivation of the gene resulted in an almost complete loss of migration activity, suggesting that TMEM18 could be a potential target in NSC-based glioma therapy. Other recent results suggest that among others, the TMEM18 loci is associated with higher than normal body mass index (BMI) and obesity, indicating there may be a CNS-related role in predisposition to obesity. Multiple isoforms of TMEM18 are known to exist.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Transmembrane protein 18
Gene Aliases: TMEM18
UniProt ID: (Human) Q96B42, (Rat) Q6DGF8
Entrez Gene ID: (Human) 129787, (Rat) 362722
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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