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Immunogen sequence: AAGGDLGWMAE TAAIITDASF LSGLSASLLE RRPASPLGPA GGLPHAPQDS VPPSDSAASD TTPLGAAVGG PSPASM
Highest antigen sequence identity to the following orthologs - mouse 47%, rat 49%.
Human membralin is unique and does not share significant sequence homology with other human genes, only membralins of other species. The membralin gene contains 11 exons which encode at least two spliced variants in human cancer. The long form of membralin (membralin-1) comprises all 11 exons, encoding a protein of 620-amino acids long and the short form of membralin (membralin-3) contains all exons except for exon 10, encoding a protein of 408 amino acids. Expression of different membralin isoforms depends on tissue type. The long form, membralin-1, is expressed in ovarian and colorectal carcinomas but not in breast or pancreatic carcinomas, which express only the short splice form, membralin-3. Recent studies suggest that membralin is a novel tumor-associated marker in ovarian serous carcinomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: aspecific BCL2 ARE-binding protein 1; Membralin; Transmembrane protein 259
Gene Aliases: ASBABP1; C19orf6; MBRL; MEMBRALIN; R32184_3; TMEM259
UniProt ID: (Human) Q4ZIN3
Entrez Gene ID: (Human) 91304
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