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Proteintech
TMEM38A Polyclonal Antibody
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Product Details
19920-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TMEM38A Fusion Protein Ag13846 (210-299 aa encoded by BC001195)
Conjugate
Form
Liquid
Concentration
0.45 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: ASLIFIFTL FMVSCKVFLT ATHSHSSPFD ALEGYICPVL FGSACGGDHH HDNHGGSHSG GGPGAQHSAM PAKSKEELSE GSRKKKAKKA D (210-299 aa encoded by BC001195)
Target Information
TMEM38A and TMEM38B are two recently identified trimeric intracellular cation (TRIC) channel subtypes. TMEM38A is preferentially expressed in excitable tissues such as striated muscle and brain and localizes to the sarcoplasmic reticulum (SR) in muscle tissues. Mice deficient in both TMEM38A and TMEM38B suffer embryonic cardiac failure; the cardiac myocytes display severe dysfunction in SR Ca2+ handling, weakened Ca2+ release, and reduced K+ permeability indicating that the TRIC cation channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores. Other experiments have shown that TMEM38A and TMEM38B can act with junctophilin proteins to support efficient ryanodine receptor-mediated Ca2+ release in muscle cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 27 kDa sarcoplasmic reticulum protein; Mitsugumin-33A; Mitsugumin33A; sarcoplasmic reticulum protein 27; SPR-27; tmem38a {ECO:0000250|UniProtKB:Q3TMP8}; Transmembrane protein 38A; TRIC-A; TRICA; Trimeric intracellular cation channel type A
Gene Aliases: 1110001E17Rik; AI413399; mg33a; RGD1307901; Srp-27; TMEM38A; TRIC-A; TRICA
UniProt ID: (Human) Q9H6F2, (Mouse) Q3TMP8, (Rat) A6ZIQ8
Entrez Gene ID: (Human) 79041, (Mouse) 74166, (Rat) 306327
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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