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Proteintech
TMEM59 Polyclonal Antibody
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Product Details
24134-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TMEM59 Fusion Protein Ag21150 (1-324 aa encoded by BC016374)
Conjugate
Form
Liquid
Concentration
0.15 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MAAPKGSLW VRTQLGLPPL LLLTMALAGG SGTASAEAFD SVLGDTASCH RACQLTYPLH TYPKEEELYA CQRGCRLFSI CQFVDDGIDL NRTKLECESA CTEAYSQSDE QYACHLGCQN QLPFAELRQE QLMSLMPKMH LLFPLTLVRS FWSDMMDSAQ SFITSSWTFY LQADDGKIVI FQSKPEIQYA PHLEQEPTNL RESSLSKMSS DLQMRNSQAH RNFLEDGESD GFLRCLSLNS GWILTTTLVL SVMVLLWICC ATVATAVEQY VPSEKLSIYG DLEFMNEQKL NRYPASSLVV VRSKTEDHEE AGPLPTKVNL AHSEI (1-324 aa encoded by BC016374)
Target Information
Processing of the amyloid precursor protein (APP) by two different proteases, called alpha- and beta-secretase, is a central regulatory event in the generation of the amyloid beta peptide (Abeta), which has a key role in Alzheimer disease (AD) pathogenesis. TMEM59, a Golgi-localized protein, modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. It inhibits APP transport and shedding.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: dendritic cell factor 1; Liver membrane-bound protein; RP4-758J24.2; Transmembrane protein 59
Gene Aliases: C1orf8; DCF1; HSPC001; PRO195; TMEM59; UNQ169; UNQ169/PRO195
UniProt ID: (Human) Q9BXS4
Entrez Gene ID: (Human) 9528
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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