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Invitrogen
TMEM59 Polyclonal Antibody
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TMEM59 Antibody (PA5-21575) in IHC (P)
TMEM59 Polyclonal Antibody detects TMEM59 protein at cytosol on human ovarian carcinoma by immunohistochemical analysis. Sample: Paraffin-embedded human ovarian carcinoma. TMEM59 Polyclonal Antibody (Product # PA5-21575) dilution: 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
Product Details
PA5-21575
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human TMEM59. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11154807
Product Specific Information
Recommended positive controls: A431, mouse liver, rat kidney.
Predicted reactivity: Mouse (95%), Rat (94%), Pig (96%), Chicken (83%), Rhesus Monkey (98%), Chimpanzee (100%), Bovine (96%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Processing of the amyloid precursor protein (APP) by two different proteases, called alpha- and beta-secretase, is a central regulatory event in the generation of the amyloid beta peptide (Abeta), which has a key role in Alzheimer disease (AD) pathogenesis. TMEM59, a Golgi-localized protein, modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. It inhibits APP transport and shedding.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: dendritic cell factor 1; Liver membrane-bound protein; RP4-758J24.2; Thymic dendritic cell-derived factor 1; Transmembrane protein 59
Gene Aliases: 1110001M20Rik; 3110046P06Rik; AI256529; C1orf8; D4Ertd20e; DCF1; HSPC001; MTDCF1; ORF18; PRO195; RGD1310313; Tdcf1; TMEM59; UNQ169; UNQ169/PRO195
UniProt ID: (Human) Q9BXS4, (Mouse) Q9QY73
Entrez Gene ID: (Human) 9528, (Mouse) 56374, (Rat) 100196907
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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