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Invitrogen
TMEM64 Polyclonal Antibody
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Product Details
PA5-112761
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Transmembrane protein 64 protein (40-118AA)
Conjugate
Form
Liquid
Concentration
4 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Wet ice
RRID
AB_2867496
Target Information
Transmembrane protein 64 (TMEM64) positively regulates TNFSF11-induced osteoclast differentiation. Acts as a regulator of TNFSF11-mediated Ca2+ signaling pathways via its interaction with SERCA2 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation. Negatively regulates osteoblast differentiation and positively regulates adipocyte differentiation via modulation of the canonical Wnt signaling pathway. Mediates the switch in lineage commitment to osteogenesis rather than to adipogenesis in mesenchymal stem cells by negatively regulating the expression, activity and nuclear localization of CTNNB1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CG11367 gene product; Transmembrane protein 64
Gene Aliases: 9630015D15Rik; AI790744; AV300874; TMEM64
UniProt ID: (Human) Q6YI46, (Mouse) Q3U145
Entrez Gene ID: (Human) 169200, (Mouse) 100201
regulation of ATPase activity
canonical Wnt signaling pathway involved in osteoblast differentiation
positive regulation of fat cell differentiation
negative regulation of osteoblast differentiation
positive regulation of osteoclast differentiation
positive regulation of bone resorption
regulation of cytosolic calcium ion concentration
negative regulation of canonical Wnt signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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