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Abnova
TMPRSS11B Polyclonal Antibody, MaxPab™
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Product Details
H00132724-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TMPRSS11B (NP_872308.1, 1 a.a. approximately 416 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MYRHGISSQR SWPLWTTIFI FLGVAAILGV TIGLLVHFLA VEKTYYYQGD FHISGVTYND NCENAASQAS TNLSKDIETK MLNAFQNSSI YKEYVKSEVI KLLPNANGSN VQLQLKFKFP PAEGVSMRTK IKAKLHQMLK NNMASWNAVP ASIKLMEISK AASEMLTNNC CGRQVANSII TGNKIVNGKS SLEGAWPWQA SMQWKGRHYC GASLISSRWL LSAAHCFAKK NNSKDWTVNF GVVVNKPYMT RKVQNIIFHE NYSSPGLHDD IALVQLAEEV SFTEYIRKIC LPEAKMKLSE NDNVVVTGWG TLYMNGSFPV ILQEAFLKII DNKICNASYA YSGFVTDSML CAGFMSGEAD ACQNDSGGPL AYPDSRNIWH LVGIVSWGDG CGKKNKPGVY TRVTSYRNWI TSKTGL
Target Information
TMPRSS11B, a member of the transmembrane serine protease family, has recently gained attention for its role in promoting tumor growth, particularly in lung squamous cell carcinomas (LSCCs). This gene is located on chromosome 4q13.2 and encodes a protein involved in proteolytic processing of substrates, impacting cellular communication and tissue homeostasis. TMPRSS11B is upregulated in LSCCs, and its high expression correlates with poor survival rates in non-small cell lung cancer patients. Research has demonstrated that TMPRSS11B facilitates metabolic reprogramming in cancer cells, aiding their transformation and proliferation. In vitro studies with immortalized human bronchial epithelial cells have shown that TMPRSS11B enhances tumor growth, indicating its potential as a therapeutic target for lung cancer treatment. Moreover, TMPRSS11B depletion in immunocompetent mice led to reduced tumor burden and increased infiltration of immune cells, suggesting its influence on the tumor microenvironment.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Airway trypsin-like protease 5; Transmembrane protease serine 11B
Gene Aliases: HATL5; TMPRSS11B
UniProt ID: (Human) Q86T26
Entrez Gene ID: (Human) 132724
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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