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Invitrogen
TMPRSS11B Polyclonal Antibody
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Product Details
PA5-31481
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the Extracellular domain of human TMPRSS11B. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 1% BSA, 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2548954
Product Specific Information
Recommended positive controls: A549, HeLa, HCT116.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
TMPRSS11B, a member of the transmembrane serine protease family, has recently gained attention for its role in promoting tumor growth, particularly in lung squamous cell carcinomas (LSCCs). This gene is located on chromosome 4q13.2 and encodes a protein involved in proteolytic processing of substrates, impacting cellular communication and tissue homeostasis. TMPRSS11B is upregulated in LSCCs, and its high expression correlates with poor survival rates in non-small cell lung cancer patients. Research has demonstrated that TMPRSS11B facilitates metabolic reprogramming in cancer cells, aiding their transformation and proliferation. In vitro studies with immortalized human bronchial epithelial cells have shown that TMPRSS11B enhances tumor growth, indicating its potential as a therapeutic target for lung cancer treatment. Moreover, TMPRSS11B depletion in immunocompetent mice led to reduced tumor burden and increased infiltration of immune cells, suggesting its influence on the tumor microenvironment.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Airway trypsin-like protease 5; Transmembrane protease serine 11B
Gene Aliases: HATL5; TMPRSS11B
UniProt ID: (Human) Q86T26
Entrez Gene ID: (Human) 132724
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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