Invitrogen

TNFAIP3 Recombinant Rabbit Monoclonal Antibody (SN07-31)

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Datasheet
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Datasheet
Protocols
Questions & Answers

Product Details

MA5-32292

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-

Flow Cytometry (Flow)

1:50-1:100
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

SN07-31

Immunogen

Synthetic peptide within Human TNFAIP3 aa 491-540
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

TBS, pH 7.4, with 40% Glycerol, 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2809577

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

TNFAIP3, also known as A20, is located in chromosome band 6q23, a region that is often deleted in B cell lymphomas. Recently, it was identified as a tumor suppressor gene in Hodgkin lymphoma and several subtypes of non-Hodgkin lymphomas. TNFAIP3 was initially identified as a zinc-finger protein that is rapidly and transiently induced by TNF-a, inhibiting NF-kappa-B-dependent gene expression, and protecting cells from TNF-a-cytotoxicity. Overexpression of TNFAIP3 also inhibits the TLR2- and TLR4-mediated interleukin-8 synthesis in airway epithelial cells, suggesting that TNFAIP3 also acts as a negative regulator of TLR-mediated inflammatory responses, thereby protecting the host against harmful over-responses to pathogens. At least two isoforms of TNFAIP3 are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: OTU domain-containing protein 7C; Putative DNA-binding protein A20; RP11-356I2.3; TNF alpha-induced protein 3; TNFAIP3 (A20); Tumor necrosis factor alpha-induced protein 3; tumor necrosis factor induced protein 3; tumor necrosis factor inducible protein A20; tumor necrosis factor, alpha induced protein 3; tumor necrosis factor, alpha-induced protein 3; Zinc finger protein A20

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Gene Aliases: A20; AISBL; OTUD7C; TNFA1P2; TNFAIP3; Tnfip3

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UniProt ID: (Human) P21580, (Mouse) Q60769

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Entrez Gene ID: (Human) 7128, (Mouse) 21929

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Function(s)
protease binding DNA binding ubiquitin-protein transferase activity thiol-dependent ubiquitin-specific protease activity protein binding zinc ion binding ligase activity kinase binding ubiquitin binding protein self-association K63-linked polyubiquitin binding catalytic activity peptidase activity cysteine-type peptidase activity UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity hydrolase activity ribosomal S6-glutamic acid ligase activity coenzyme F420-0 gamma-glutamyl ligase activity coenzyme F420-2 alpha-glutamyl ligase activity metal ion binding protein-glycine ligase activity protein-glycine ligase activity, initiating protein-glycine ligase activity, elongating tubulin-glycine ligase activity protein-glutamic acid ligase activity tubulin-glutamic acid ligase activity
Process(es)
B-1 B cell homeostasis response to molecule of bacterial origin marginal zone B cell differentiation negative regulation of granuloma formation regulation of germinal center formation regulation of immunoglobulin production negative regulation of chronic inflammatory response proteolysis apoptotic process inflammatory response metabolic process response to wounding negative regulation of autophagy protein deubiquitination negative regulation of protein ubiquitination negative regulation of NF-kappaB transcription factor activity response to muramyl dipeptide negative regulation of interleukin-1 beta production negative regulation of interleukin-2 production negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production negative regulation of heterotypic cell-cell adhesion negative regulation of toll-like receptor 3 signaling pathway negative regulation of toll-like receptor 5 signaling pathway protein K11-linked deubiquitination negative regulation of I-kappaB kinase/NF-kappaB signaling regulation of innate immune response positive regulation of protein catabolic process negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of innate immune response negative regulation of smooth muscle cell proliferation negative regulation of inflammatory response negative regulation of B cell activation negative regulation of cell death cellular response to hydrogen peroxide negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway protein K63-linked deubiquitination protein K48-linked ubiquitination protein K48-linked deubiquitination cellular response to lipopolysaccharide tolerance induction to lipopolysaccharide establishment of protein localization to vacuole negative regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of cellular protein catabolic process positive regulation of hepatocyte proliferation negative regulation of CD40 signaling pathway negative regulation of endothelial cell apoptotic process regulation of tumor necrosis factor-mediated signaling pathway negative regulation of type I interferon production negative regulation of toll-like receptor 2 signaling pathway negative regulation of toll-like receptor 4 signaling pathway negative regulation of bone resorption regulation of defense response to virus by host regulation of inflammatory response protein oligomerization regulation of vascular wound healing nucleotide-binding oligomerization domain containing signaling pathway protein deubiquitination involved in ubiquitin-dependent protein catabolic process negative regulation of osteoclast proliferation
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