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Bioss
TNFAIP5 Polyclonal Antibody
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Product Details
BS-5783R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human TNFAIP5/Pentraxin 3, amino acids 151-250.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Pentraxins are a protein superfamily that is characterized by a cyclic multimeric structure. Ptx3, also known as tumor necrosis factor-stimulated gene sequence-14 (TSG14), is a secreted pattern-recognition receptor that has a non-redundant role in resistance to selected microbial agents. Ptx3 belongs to the family of "long pentraxins", which have C-terminal pentraxin domains and novel amino-terminal domains. Ptx3 binds selected pathogens, including Aspergillus fumigatus, Pseudomonas aeruginosa and Salmonella typhimurium. It is synthesized in IgA glomerulonephritis and activates mesangial cells. Secretion of Ptx3 in adipose cells can be induced by TNF. Ptx3 is also involved in amplification of inflammatory reactions and regulation of innate immunity. The human PTX3 gene maps to chromosome 3q25.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: long pentraxin 3; pentaxin related; Pentaxin-related protein PTX3; pentraxin 3; pentraxin related; Pentraxin-related protein PTX3; TNF alpha-induced protein 5; TSG-14; Tumor necrosis factor alpha-induced protein 5; Tumor necrosis factor-inducible gene 14 protein; tumor necrosis factor-inducible protein TSG-14
Gene Aliases: AI607804; PTX3; TNFAIP5; TSG-14; TSG14
UniProt ID: (Human) P26022, (Mouse) P48759
Entrez Gene ID: (Human) 5806, (Mouse) 19288, (Rat) 689388
response to yeast
inflammatory response
opsonization
negative regulation by host of viral exo-alpha-sialidase activity
negative regulation by host of viral glycoprotein metabolic process
innate immune response
positive regulation of nitric oxide biosynthetic process
negative regulation of viral entry into host cell
positive regulation of phagocytosis
negative regulation of exo-alpha-sialidase activity
negative regulation of glycoprotein metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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