Invitrogen

TNFR1 Polyclonal Antibody

1 Published Figure

View all (58) TNFR1 antibodies

Questions & Answers

Questions & Answers

Published Figures (1)

TNFR1 Antibody in Western Blot (WB)

TNFR1 Antibody in Western Blot (WB)

FIGURE: 1 / 1

TNFR1 Antibody (PA1-40282) in WB

Cytokine 2014 - Published figure using TNFR1 polyclonal antibody (Product # PA1-40282) in Western Blot

TNFR1 Antibody in Western Blot (WB)

Product Image Gallery

TNFR1 Antibody in Western Blot (WB) — Published figure using TNFR1 polyclonal antibody (Product # PA1-40282) in Western Blot

Product Details

PA1-40282

Applications

Tested Dilution

Publications

Western Blot (WB)

1:50

View 1 publication 1 publication

Flow Cytometry (Flow)

1:50

-

ELISA (ELISA)

1:50

-

Immunoprecipitation (IP)

1:50

-

Functional Assay (Functional)

1:50

-

Product Specifications

Species Reactivity

Mouse

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Extracellular region of murine TNF-R I.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Protein A

Storage buffer

PBS with 0.1% BSA

Contains

no preservative

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_1087960

Product Specific Information

PA1-40282 detects TNF-R I from mouse samples.

PA1-40282 has been successfully used in ELISA, functional assays, flow cytometry, immunoprecipitation, and Western blot applications.

The PA1-40282 imunogen is the extracellular region of mouse TNF-R I.

Endotoxin <24 EU/mg.

Target Information

TNFR1 (Tumor necrosis factor receptor 1) belongs to the tumor necrosis factor superfamily, and is one of the major TNF-alpha receptors. TNFR1 plays an important role in mediating, in cytokine mediated signaling, positive regulation of the NF-Kb pathway, positive regulation of angiogenesis, and negative regulation of gene expression. The extracellular domain of TNFR1 is also released into the circulatory system as soluble TNFR1 (sTNFR1). In humans, the TNFR1 gene is located on chromosome 12. Anti-apoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with TNFR1, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of TNFR1 were found to be associated with the autosomal dominant periodic fever syndrome, and the impaired receptor clearance is thought to be a mechanism of the disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Loss of STAT3 in mouse embryonic fibroblasts reveals its Janus-like actions on mitochondrial function and cell viability.

Cytokine

Zouein FA,Duhé RJ,Arany I,Shirey K,Hosler JP,Liu H,Saad I,Kurdi M,Booz GW

PA1-40282 was used in western blot to study the role of STAT3 in mitochondrial function and cell viability using STAT3 knockout murine embryonic fibroblasts

Sat Mar 01 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: CD120a; CD120a antigen; MGC19588; n-smase activation assoc. factor; p55; p60; p62; p63; sCD120a; soluble CD120a; soluble TNFR1; sTNF RI; sTNFR I; sTNFR1; sTNFRI; TNF receptor alpha chain; TNF-alpha-R1; TNF-R1; TNF-RI; TNFR; TNFR I; TNFR-I; Tumor necrosis factor receptor; Tumor necrosis factor receptor 1; Tumor necrosis factor receptor superfamily member 1A; Tumor necrosis factor receptor type I

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Gene Aliases: CD120a; FPF; p55; p55-R; TNF-alphaR1; TNF-R; TNF-R-I; TNF-R1; TNF-R55; TNFalpha-R1; TNFAR; Tnfr-1; Tnfr-2; Tnfr1; TNFR60; TNFRI; TNFRp55; Tnfrsf1a

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UniProt ID: (Mouse) P25118

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Entrez Gene ID: (Mouse) 21937

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protease binding tumor necrosis factor-activated receptor activity protein binding protein complex binding tumor necrosis factor binding

prostaglandin metabolic process apoptotic process defense response inflammatory response signal transduction cell surface receptor signaling pathway intrinsic apoptotic signaling pathway in response to DNA damage positive regulation of gene expression negative regulation of gene expression programmed cell death cytokine-mediated signaling pathway negative regulation of interleukin-6 production positive regulation of tumor necrosis factor production positive regulation of protein import into nucleus, translocation tumor necrosis factor-mediated signaling pathway positive regulation of tyrosine phosphorylation of Stat1 protein defense response to bacterium regulation of apoptotic process negative regulation of apoptotic process positive regulation of neuron apoptotic process positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter negative regulation of inflammatory response positive regulation of inflammatory response protein heterooligomerization

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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