Invitrogen

TNFR1 Monoclonal Antibody (H398)

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TNFR1 Antibody (33-0100)

IP-MS enrichment of TNFRSF1A (LFQ intensity): TNFRSF1A was enriched 463-fold from A549 lysate compared to background proteins, using the optimized IP-MS workflow with Pierce MS-Compatible Magnetic IP Kit protein A/G (Product # 90409) and TNFRSF1A antibody (Product # 33-0100). The STRING database (www.string-db.org) was used to identify the protein interactor list. See more information on IP-MS verification ... View More

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TNFR1 Antibody — IP-MS enrichment of TNFRSF1A (LFQ intensity): TNFRSF1A was enriched 463-fold from A549 lysate compared to background proteins, using the optimized IP-MS workflow with Pierce MS-Compatible Magnetic IP Kit protein A/G (Product # 90409) and TNFRSF1A antibody (Product # 33-0100). The STRING database (www.string-db.org) was used to identify the protein interactor list. See more information on IP-MS verification of antibody selectivity. {IP-MS}

Product Details

33-0100

Applications

Tested Dilution

Publications

Western Blot (WB)

View 1 publication 1 publication

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Frozen) (IHC (F))

1:150

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Flow Cytometry (Flow)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human, Mouse, Rabbit

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

H398

Immunogen

Recombinant human sTNF-r.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_2533098

Target Information

TNFR1 (Tumor necrosis factor receptor 1) belongs to the tumor necrosis factor superfamily, and is one of the major TNF-alpha receptors. TNFR1 plays an important role in mediating, in cytokine mediated signaling, positive regulation of the NF-Kb pathway, positive regulation of angiogenesis, and negative regulation of gene expression. The extracellular domain of TNFR1 is also released into the circulatory system as soluble TNFR1 (sTNFR1). In humans, the TNFR1 gene is located on chromosome 12. Anti-apoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with TNFR1, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of TNFR1 were found to be associated with the autosomal dominant periodic fever syndrome, and the impaired receptor clearance is thought to be a mechanism of the disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Salivary Gland Stem Cells Age Prematurely in Primary Sjögren's Syndrome.

Arthritis & rheumatology (Hoboken, N.J.)

Pringle S,Wang X,Verstappen GMPJ,Terpstra JH,Zhang CK,He A,Patel V,Jones RE,Baird DM,Spijkervet FKL,Vissink A,Bootsma H,Coppes RP,Kroese FGM

33-0100 was used in Immunocytochemistry-immunoflourescence to investigate the role of salivary gland stem cells in hyposalivation in primary SS.

Tue Jan 01 00:00:00 UTC 2019

The Effects of Anti-Vascular Endothelial Growth Factor Drugs on Retinal Pigment Epithelial Cell Culture.

Turkish journal of ophthalmology

Şahiner M,Bahar D,Öner A,Gönen ZB,Ünlü M,Gülmez Sevim D,Karaca Ç,Mirza GE

33-0100 was used in Immunocytochemistry-immunoflourescence to assess the effects of anti-vascular endothelial growth factor drugs on retinal pigment epithelium cell culture.

Wed Aug 01 00:00:00 UTC 2018

Neutrophils promote aerogenous spread of lung adenocarcinoma with bronchioloalveolar carcinoma features.

Clinical cancer research : an official journal of the American Association for Cancer Research

Wislez M,Antoine M,Rabbe N,Gounant V,Poulot V,Lavolé A,Fleury-Feith J,Cadranel J

Fri Jun 15 00:00:00 UTC 2007

Interleukin-6 deficiency reduces the brain inflammatory response and increases oxidative stress and neurodegeneration after kainic acid-induced seizures.

Neuroscience

Penkowa M,Molinero A,Carrasco J,Hidalgo J

Thu May 17 00:00:00 UTC 2001

A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling.

Science (New York, N.Y.)

Chan FK,Chun HJ,Zheng L,Siegel RM,Bui KL,Lenardo MJ

Fri Jun 30 00:00:00 UTC 2000

A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling.

Science (New York, N.Y.)

Chan FK,Chun HJ,Zheng L,Siegel RM,Bui KL,Lenardo MJ

Fri Jun 30 00:00:00 UTC 2000

Human immunodeficiency virus type 1 Nef mediates sustained membrane expression of tumor necrosis factor and the related cytokine LIGHT on activated T cells.

Journal of virology

Lama J,Ware CF

33-0100 was used in Flow Cytometry to study the effects of HIV Nef on surface expression of the effector cytokines tumour necrosis factor and LIGHT.

Sun Oct 01 00:00:00 UTC 2000

Bioinformatics

Protein Aliases: CD120a; CD120a antigen; MGC19588; n-smase activation assoc. factor; p55; p60; p62; p63; sCD120a; soluble CD120a; soluble TNFR1; sTNF RI; sTNFR I; sTNFR1; sTNFRI; TNF-R1; TNF-RI; TNFR; TNFR I; TNFR-I; tumor necrosis factor binding protein 1; Tumor necrosis factor receptor; Tumor necrosis factor receptor 1; tumor necrosis factor receptor 1A isoform beta; Tumor necrosis factor receptor superfamily member 1A; tumor necrosis factor receptor superfamily, member 1A; tumor necrosis factor receptor type 1; Tumor necrosis factor receptor type I; tumor necrosis factor-alpha receptor

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Gene Aliases: CD120a; FPF; MS5; p55; p55-R; p60; TBP1; TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55; TNFR60; TNFRSF1A

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UniProt ID: (Human) P19438

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Entrez Gene ID: (Human) 7132

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Function(s)

tumor necrosis factor-activated receptor activity protein binding tumor necrosis factor binding

Process(es)

prostaglandin metabolic process inflammatory response immune response I-kappaB kinase/NF-kappaB signaling extrinsic apoptotic signaling pathway via death domain receptors intrinsic apoptotic signaling pathway in response to DNA damage regulation of tumor necrosis factor-mediated signaling pathway viral process cytokine-mediated signaling pathway response to lipopolysaccharide tumor necrosis factor-mediated signaling pathway regulation of cell proliferation positive regulation of tyrosine phosphorylation of Stat1 protein defense response to bacterium regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of transcription from RNA polymerase II promoter negative regulation of inflammatory response positive regulation of inflammatory response cellular response to mechanical stimulus death-inducing signaling complex assembly establishment of protein localization to plasma membrane regulation of establishment of endothelial barrier positive regulation of ceramide biosynthetic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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TNFR1 Monoclonal Antibody (H398)

TNFR1 Antibody (33-0100)

Product Details

33-0100

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Frozen) (IHC (F))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Target Information

Bioinformatics

Performance Guarantee

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