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Invitrogen
TNFRH3 Monoclonal Antibody (509027)
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Product Details
MA5-24220
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rat
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
509027
Immunogen
CHO-derived recombinant mouse TNFRH3/TNFRSF26 Ser20-Lys162
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Purification
Protein A/G
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2608239
Product Specific Information
In direct ELISAs, no cross-reactivity with recombinant mouse (rm) Fas, rmTNF RI, and rmTNF RII is observed.
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
The TNFRH3 gene encodes a protein that is part of the tumor necrosis factor receptor superfamily, which is involved in regulating immune responses, inflammation, and apoptosis. TNFRH3, also identified as tumor necrosis factor receptor homolog 3, is characterized by its similarities to other TNF receptors, yet its specific ligand and signaling pathways remain an area of active research. TNF receptors typically engage in critical interactions with ligands such as TNF-a, facilitating cellular responses that include the modulation of immune cell function, survival, and proliferation. Although TNFRH3's precise function is not fully elucidated, it is hypothesized to play a role in modulating immune signaling and inflammatory responses, potentially impacting autoimmune disease processes and cancer progression by influencing apoptosis and cell survival. Like other members of the TNF receptor family, TNFRH3 might interact with adaptor proteins to form signaling complexes that propagate downstream effects critical for immune homeostasis. Research efforts continue to define its role in physiological and pathological states, aiming to leverage its function for therapeutic applications in treating inflammatory diseases and cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: TNF receptor homolog 3; TNFR; Tumor necrosis factor receptor; Tumor necrosis factor receptor superfamily member 26; tumor necrosis factor receptor superfamily, member 24
Gene Aliases: Tnfrh3; Tnfrsf24; Tnfrsf26
UniProt ID: (Mouse) P83626
Entrez Gene ID: (Mouse) 244237
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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