Proteintech

TNK1 Polyclonal Antibody

TNK1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 10

TNK1 Antibody (14199-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human prostate cancer tissue slide using 14199-1-AP ( TNK1 antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

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Product Details

14199-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 2 publications 2 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TNK1 Fusion Protein Ag5402 (1-377 aa encoded by BC035782)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MLPEAGSLW LLKLLRDIQL AQFYWPILEE LNVTRPEHFD FVKPEDLDGI GMGRPAQRRL SEALKRLRSG PKSKNWVYKI LGGFAPEHKE PTLPSDSPRH LPEPEGGLKC LIPEGAVCRG ELLGSGCFGV VHRGLWTLPS GKSVPVAVKS LRVGPEGPMG TELGDFLREV SVMMNLEHPH VLRLHGLVLG QPLQMVMELA PLGSLHARLT APAPTPPLLV ALLCLFLRQL AGAMAYLGAR GLVHRDLATR NLLLASPRTI KVADFGLVRP LGGARGRYVM GGPRPIPYAW CAPESLRHGA FSSASDVWMF GVTLWEMFSG GEEPWAGVPP YLILQRLEDR ARLPRPPLCS RALYSLALRC WAPHPADRPS FSHLEGLL (1-377 aa encoded by BC035782)

Target Information

TNK1 tyrosine kinase, non-receptor 1 belongs to the tyrosine protein kinase family and as such is an important regulator of intracellular signal transduction pathways mediating cellular proliferation, survival, and development. TNK1 is highly expressed in fetal tissues and at lower levels in a few adult tissues. TNK1 may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. TNK1 plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Tyrosine kinase nonreceptor 1 (TNK1) knockdown ameliorates hemorrhage shock-induced kidney injury via inhibiting macrophage M1 polarization.

3 Biotech

Tang M,Cai J,Wang Y,Huan Z,Yao H,Xu C,Ge X,Song S

Wed Dec 01 00:00:00 UTC 2021

Tyrosine kinase nonreceptor 1 (TNK1) knockdown ameliorates hemorrhage shock-induced kidney injury via inhibiting macrophage M1 polarization.

3 Biotech

Tang M,Cai J,Wang Y,Huan Z,Yao H,Xu C,Ge X,Song S

Wed Dec 01 00:00:00 UTC 2021

Tyrosine kinase nonreceptor 1 (TNK1) knockdown ameliorates hemorrhage shock-induced kidney injury via inhibiting macrophage M1 polarization.

3 Biotech

Tang M,Cai J,Wang Y,Huan Z,Yao H,Xu C,Ge X,Song S

Wed Dec 01 00:00:00 UTC 2021

Tyrosine kinase nonreceptor 1 (TNK1) knockdown ameliorates hemorrhage shock-induced kidney injury via inhibiting macrophage M1 polarization.

3 Biotech

Tang M,Cai J,Wang Y,Huan Z,Yao H,Xu C,Ge X,Song S

Wed Dec 01 00:00:00 UTC 2021

Thirty-Eight-Negative Kinase 1 Is a Mediator of Acute Kidney Injury in Experimental and Clinical Traumatic Hemorrhagic Shock.

Frontiers in immunology

Halbgebauer R,Karasu E,Braun CK,Palmer A,Braumüller S,Schultze A,Schäfer F,Bückle S,Eigner A,Wachter U,Radermacher P,Resuello RRG,Tuplano JV,Nilsson Ekdahl K,Nilsson B,Armacki M,Kleger A,Seufferlein T,Kalbitz M,Gebhard F,Lambris JD,van Griensven M,Huber-Lang M

Thu May 20 00:00:00 UTC 2021

Bioinformatics

Protein Aliases: CD38 negative kinase 1; Kinase of embryonic stem cells; MGC46193; non-receptor tyrosine kinase; Non-receptor tyrosine-protein kinase TNK1; TNK1; tyrosine kinase, non-receptor 1; tyrosine kinase, non-receptor, 1

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Gene Aliases: Kos1; TNK1; Tnk1a; Tnk1b

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UniProt ID: (Human) Q13470, (Mouse) Q99ML2

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Entrez Gene ID: (Human) 8711, (Rat) 303247, (Mouse) 83813

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Function(s)

protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity signal transducer activity receptor binding protein binding ATP binding hormone receptor binding nucleotide binding protein kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups

Process(es)

protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway cell differentiation negative regulation of cell growth peptidyl-tyrosine autophosphorylation regulation of cell proliferation innate immune response negative regulation of Ras protein signal transduction protein autophosphorylation cell migration peptidyl-tyrosine phosphorylation phosphorylation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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TNK1 Polyclonal Antibody

TNK1 Antibody (14199-1-AP) in IHC (P)

Product Details

14199-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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