Proteintech

TNNC1 Polyclonal Antibody

TNNC1 Antibody in Immunocytochemistry (ICC/IF)

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TNNC1 Antibody (13504-1-AP) in ICC/IF

Immunofluorescent analysis of ( 4% PFA) fixed U2OS cells using 13504-1-AP (TNNC1 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

TNNC1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

TNNC1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

13504-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:50

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TNNC1 Fusion Protein Ag4339 (1-161 aa encoded by BC030244)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.57 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MDDIYKAAV EQLTEEQKNE FKAAFDIFVL GAEDGCISTK ELGKVMRMLG QNPTPEELQE MIDEVDEDGS GTVDFDEFLV MMVRCMKDDS KGKSEEELSD LFRMFDKNAD GYIDLDELKI MLQATGETIT EDDIEELMKD GDKNNDGRID YDEFLEFMKG VE (1-161 aa encoded by BC030244)

Target Information

Troponin (Tn) is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments, and as a result of calcium-ion uptake by troponin-C, the elements of the muscle thin filament undergo a series of allosteric changes which allow the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

GSK-J4, a Specific Histone Lysine Demethylase 6A Inhibitor, Ameliorates Lipotoxicity to Cardiomyocytes via Preserving H3K27 Methylation and Reducing Ferroptosis.

Frontiers in cardiovascular medicine

Xu K,Liu X,Wen B,Liu Y,Zhang W,Hu X,Chen L,Hang W,Chen J

Sat Jul 16 00:00:00 UTC 2022

GSK-J4, a Specific Histone Lysine Demethylase 6A Inhibitor, Ameliorates Lipotoxicity to Cardiomyocytes via Preserving H3K27 Methylation and Reducing Ferroptosis.

Frontiers in cardiovascular medicine

Xu K,Liu X,Wen B,Liu Y,Zhang W,Hu X,Chen L,Hang W,Chen J

Sat Jul 16 00:00:00 UTC 2022

TNNC1 Reduced Gemcitabine Sensitivity of Nonsmall-Cell Lung Cancer by Increasing Autophagy.

Medical science monitor : international medical journal of experimental and clinical research

Ye X,Xie G,Liu Z,Tang J,Cui M,Wang C,Guo C,Tang J

Fri Sep 18 00:00:00 UTC 2020

LukS-PV Inhibits Hepatocellular Carcinoma Cells Migration via the TNNC1/PI3K/AKT Axis.

OncoTargets and therapy

Ma F,Wang Z,Qiang Y,Xu L,Ding P,Wang Y,Ma X

Sun Apr 17 00:00:00 UTC 2022

iTRAQ-Based Proteomic Analysis Reveals Recovery of Impaired Mitochondrial Function in Ischemic Myocardium by Shenmai Formula.

Journal of proteome research

Wang Y,Zhao Y,Jiang W,Zhao X,Fan G,Zhang H,Shen P,He J,Fan X

Fri Feb 02 00:00:00 UTC 2018

iTRAQ-Based Proteomic Analysis Reveals Recovery of Impaired Mitochondrial Function in Ischemic Myocardium by Shenmai Formula.

Journal of proteome research

Wang Y,Zhao Y,Jiang W,Zhao X,Fan G,Zhang H,Shen P,He J,Fan X

Fri Feb 02 00:00:00 UTC 2018

MUNC, an Enhancer RNA Upstream from the MYOD Gene, Induces a Subgroup of Myogenic Transcripts in trans Independently of MyoD.

Molecular and cellular biology

Cichewicz MA,Kiran M,Przanowska RK,Sobierajska E,Shibata Y,Dutta A

Mon Oct 15 00:00:00 UTC 2018

Calcium-dependent FAK/CREB/TNNC1 signalling mediates the effect of stromal MFAP5 on ovarian cancer metastatic potential.

Nature communications

Leung CS,Yeung TL,Yip KP,Pradeep S,Balasubramanian L,Liu J,Wong KK,Mangala LS,Armaiz-Pena GN,Lopez-Berestein G,Sood AK,Birrer MJ,Mok SC

Fri Oct 03 00:00:00 UTC 2014

Calcium-dependent FAK/CREB/TNNC1 signalling mediates the effect of stromal MFAP5 on ovarian cancer metastatic potential.

Nature communications

Leung CS,Yeung TL,Yip KP,Pradeep S,Balasubramanian L,Liu J,Wong KK,Mangala LS,Armaiz-Pena GN,Lopez-Berestein G,Sood AK,Birrer MJ,Mok SC

Fri Oct 03 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: cardiac 3; cardiac troponin C; Cardiac troponin I; CMD1FF; CMD2A; CMH7; MGC116817; RCM1; slow twitch skeletal/cardiac muscle troponin C; TN-C; Tn1; Tni; TNN I3; TNNC 1; TNNI3; troponin C type 1 (slow); troponin C, cardiac/slow skeletal; Troponin C, slow skeletal and cardiac muscles; troponin C1, slow; Troponin I; Troponin I cardiac; TroponinI

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Gene Aliases: AI874626; CMD1Z; CMH13; cTnC; cTnI; TN-C; TNC; Tncc; TNNC; TNNC1

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UniProt ID: (Human) P63316, (Mouse) P19123

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Entrez Gene ID: (Human) 7134, (Rat) 290561, (Mouse) 21924

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Function(s)

calcium ion binding protein binding troponin I binding troponin T binding protein homodimerization activity calcium-dependent protein binding actin filament binding metal ion binding

Process(es)

diaphragm contraction skeletal muscle contraction regulation of muscle contraction response to metal ion transition between fast and slow fiber muscle filament sliding regulation of muscle filament sliding speed regulation of ATPase activity ventricular cardiac muscle tissue morphogenesis cardiac muscle contraction

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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TNNC1 Polyclonal Antibody

TNNC1 Antibody (13504-1-AP) in ICC/IF

Product Details

13504-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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