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Proteintech
TNNI2 Polyclonal Antibody
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Product Details
11634-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TNNI2 Fusion Protein Ag2208 (1-182 aa encoded by BC032148)
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MGDEEKRNR AITARRQHLK SVMLQIAATE LEKEESRREA EKQNYLAEHC PPLHIPGSMS EVQELCKQLH AKIDAAEEEK YDMEVRVQKT SKELEDMNQK LFDLRGKFKR PPLRRVRMSA DAMLKALLGS KHKVCMDLRA NLKQVKKEDT EKERDLRDVG DWRKNIEEKS GMEGRKKMFE SES (1-182 aa encoded by BC032148)
Target Information
This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: troponin 1, type 2; troponin I fast twitch 2; troponin I type 2 (skeletal, fast); Troponin I, fast skeletal muscle; Troponin I, fast-twitch isoform; troponin I, fast-twitch skeletal muscle isoform; troponin I, skeletal, fast; troponin I, skeletal, fast 2
Gene Aliases: AMCD2B; DA2B; FSSV; fsTnI; TNNI2; Trp1
UniProt ID: (Human) P48788, (Rat) P27768, (Mouse) P13412
Entrez Gene ID: (Human) 7136, (Rat) 29389, (Mouse) 21953
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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