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Invitrogen
TNNI2 Monoclonal Antibody (2F12A11)
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Product Details
MA5-15911
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rabbit
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2F12A11
Immunogen
Purified recombinant fragment of human TNNI2 expressed in E. Coli.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.03% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11157876
Product Specific Information
MA5-15911 targets TNNI2 in indirect ELISA, FACS, IHC, and WB applications and shows reactivity with Human samples.
The MA5-15911 immunogen is purified recombinant fragment of human TNNI2 expressed in E. Coli. .
MA5-15911 detects TNNI2 which has a predicted molecular weight of approximately 21kDa.
Target Information
This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: troponin I fast twitch 2; troponin I type 2 (skeletal, fast); Troponin I, fast skeletal muscle; Troponin I, fast-twitch isoform; troponin I, fast-twitch skeletal muscle isoform; troponin I, skeletal, fast
Gene Aliases: AMCD2B; DA2B; FSSV; fsTnI; TnI; TNNI2
UniProt ID: (Human) P48788, (Rabbit) P02643, (Mouse) P13412
Entrez Gene ID: (Human) 7136, (Rabbit) 100009581, (Mouse) 21953
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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